Low-molecular-weight heparins (LMWH) appear to prolong survival of patients with cancer.
Such a beneficial effect is thought to be associated with interruption of molecular …

Publisher Summary This chapter describes the structure and biological activity of heparin.
Being an alternating copolymer of a hexosamine and an alduronic acid, heparin belongs to …

A small fraction of plasma antithrombin is normally bound to a specific population of heparan
sulfate proteoglycans synthesized by macrovascular and microvascular endothelial cells …

The heparan sulfate (HS) chains of heparan sulfate proteoglycans (HSPG) are “ubiquitous”
components of the cell surface and the extracellular matrix (EC) and play important roles in …

Liquid chromatography/mass spectrometry (LC/MS) is applied to the analysis of complex
mixtures of oligosaccharides obtained through the controlled, heparinase-catalyzed …

A method for the preparation of heparan sulfate from peptidoglycan heparin is described.
The objective of this research was to provide a basis for the development and validation of …

The D-glucuronosyl-(GlcA) and N-acetyl-D-glucosaminyl-(GlcNAc) transferase reactions
involved in heparin/heparan sulfate biosynthesis were assayed, measuring transfer of …

Heparin with a molecular weight of 1.1 x 10 6 and sedimentation coefficient of 12.8 S has
been isolated from Pronase-digested rat skin. The limiting viscosity number of this product is …

A detailed knowledge about the substrate specificities of the heparin lyases is necessary
when using these enzymes as tools for elucidating the sequence of heparin and heparan …

The structure of human skin fibroblast heparan sulphate has been examined by
depolymerization with heparinase, which specifically cleaves highly sulphated …