Methionine demethylation during metabolism generates homocysteine (Hcy) and its
remethylation requires folate and cobalamin. Elevated Hcy concentrations are associated …

Background: Increased total homocysteine (tHcy) may be associated with placental-
mediated adverse pregnancy outcomes, but few prospective studies have measured tHcy …

Objective: To measure fetal and maternal plasma homocysteine (Hcy) concentrations in
uncomplicated pregnancies. Methods: Paired maternal venous and fetal umbilical cord …

Total fasting plasma homocysteine (tHcy) is significantly reduced during early–mid normal
pregnancy. Elevated tHcy during or outside of pregnancy has been associated with adverse …

Objective To analyse the pregnancy outcome by combining plasma homocysteine with
uterine artery Doppler velocimetry at 11 to 14 weeks of gestation. Method A prospective …

Homocysteine is an amino acid that is involved in several key metabolic processes,
including the methylation and sulphuration pathways. Blood concentrations of homocysteine …

Introduction Maternal elevated plasma total homocysteine (tHcy) is involved in the origin of
several placenta-related pregnancy complications. The first trimester is the most sensitive …

Homocysteine is associated with endothelial dysfunction and cardiovascular disease, and
elevated concentrations of homocysteine have been found in preeclampsia. The purpose of …

Objective: To investigate whether mid-trimester maternal plasma homocysteine
concentration is elevated in women who develop pre-eclampsia and in those women …

Increased homocysteine is associated with the pregnancy complication preeclampsia and
with later-life cardiovascular disease. Although elevated homocysteine persists after …