The design of randomised controlled trials (RCTs) should incorporate characteristics (such
as concealment of randomised allocation and blinding of participants and personnel) that …

Background There is controversy about the value of evidence about the effectiveness of
healthcare interventions from non-randomised study designs. Advocates for quasi …

Objective To synthesise evidence on the average bias and heterogeneity associated with
reported methodological features of randomized trials. Design Systematic review of meta …

Background There has been a recent increase in interest in alternatives to randomisation in
the evaluation of public health interventions. We aim to describe specific scenarios in which …

OBJECTIVE: To test the feasibility of creating a valid and reliable checklist with the following
features: appropriate for assessing both randomised and non-randomised studies; provision …

OBJECTIVES: To consider methods and related evidence for evaluating bias in non-
randomised intervention studies. DATA SOURCES: Systematic reviews and methodological …

In an era characterized by an emphasis on evidence-informed practice, research plays a
central role in helping us understand human conditions, behaviors, and emerging problems; …

Some authors argue that systematic reviews and meta-analyses of intervention studies
should include only randomized controlled trials because the randomized controlled trial is a …

Background When designing a randomised controlled trial (RCT), an important
consideration is the sample size required. This is calculated from several components; one …

Recent years have seen increasing interest in and attention to evidence-based practices,
where the “evidence” generally comes from well-conducted randomized trials. However …