Oocytes are maintained in a state of meiotic arrest following the first meiotic division until
ovulation is triggered. Within the antral follicle, meiotic arrest is actively suppressed in a …

Cyclin B1, the regulatory component of M phase-promoting factor (MPF), is degraded during
the metaphase-anaphase transition in an anaphase-promoting complex/cyclosome (APC/C) …

The hormone-independent, spontaneous maturation that rat oocytes undergo in vitro can be
inhibited by derivatives of cyclic AMP and inhibitors of cyclic nucleotide phosphodiesterase …

In maturing mouse oocytes, protein synthesis is required for meiotic maturation subsequent
to germinal vesicle breakdown (GVBD). While the number of different proteins that must be …

The effect of adenylate cyclase stimulation via the components of the enzyme on nuclear
maturation in bovine cumulus-enclosed and zona-free oocytes was examined. The …

Mammalian oocytes are arrested at the diplotene phase of the first meiotic division until
ovulation. In the mouse, germinal vesicle breakdown (GVBD) and progression to metaphase …

In most mammals, meiotic maturation is initiated near the time of biih when oogonia cease
proliferating and enter prophase I of meiosis. The germ cells, now referred to as oocytes …

Invasive adenylate cyclase (iAC) reversibly inhibits spontaneous maturation of cumulus-
enclosed bovine oocytes by increasing the intracellular concentration of cAMP,[cAMP] i. In …

Under the influence of gonadotropins or growth factors, a close cooperation develops
between cumulus cells and the oocyte that is implicated in transmitting signals involved in …

Acquisition of oocyte developmental competence needs to be understood to improve clinical
outcomes of assisted reproduction. The stimulation of cumulus cell concentration of cyclic …