Abstract cAMP synthesis by the rat oocyte and cumulus-oocyte complex was studied using
direct labeling techniques. Cumulus-oocyte complexes synthesized cAMP in response to …

Mouse oocytes undergo spontaneous meiotic maturation when cultured in vitro in the
absence, but not in the presence, of dibutyryl cyclic AMP (cAMP). Furthermore, the inhibition …

The development of the ovarian follicle, oocyte maturation, and ovulation require a complex
set of endocrine, paracrine, and autocrine inputs that are translated into the regulation of …

A shift from a meiotic cell cycle to a mitotic cell cycle occurs following fertilization. The
molecular basis for this transition, however, is poorly understood. Although cyclin A1 is …

The hypothesis that cumulus cells inhibit oocyte maturation by a cAMP-dependent process
was tested (RM Schultz, R. Montgomery, PF Ward-Bailey, and JJ Eppig (1983). Dev. Biol …

Acquisition of oocyte developmental competence needs to be understood to improve clinical
outcomes of assisted reproduction. The stimulation of cumulus cell concentration of cyclic …

The present study was designed to address the physiological role played by cAMP on gap
junction (GJ) mediated communications between oocyte and cumulus cells during in vitro …

Cumulus cell‐enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were
obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats …

Cumulus cells sustain the development and fertilization of the mammalian oocyte. These
cells are retained around the oocyte by a hyaluronan-rich extracellular matrix synthesized …

We compared the profile of histone H1 kinase activity, reflecting Maturation Promoting Factor
(MPF) activity in oocytes bisected at the germinal vesicle (GV) stage and allowed to mature …