Cumulus cells sustain the development and fertilization of the mammalian oocyte. These
cells are retained around the oocyte by a hyaluronan-rich extracellular matrix synthesized …

The extracellular cAMP-adenosine pathway refers to the local production of adenosine
mediated by cAMP egress into the extracellular space, conversion of cAMP to AMP by …

Vertebrate oocytes arrest at prophase of meiosis I as a result of high levels of cyclic
adenosine monophosphate (cAMP) and protein kinase A (PKA) activity. In Xenopus …

The relationship between cAMP and the capacity of two partially-purified fractions of porcine
follicular fluid (PFF) to suppress mouse oocyte maturation was investigated. The fractions …

Mammalian oocytes spend the majority of their lives in a dormant state, residing in
primordial follicles. This arrest, most analogous to the G2 stage of the mitotic cell cycle …

Oocyte meiotic maturation is a vital and final process in oogenesis. Unlike somatic cells, the
oocyte needs to undergo two continuous meiotic divisions (meiosis I and meiosis II) to …

The control of protein synthesis during maturation in oocytes is mainly exerted through
cytoplasmic polyadenylation of stored mRNAs. We first analyzed the polyadenylation status …

Forskolin, a diterpene that activates rapidly adenylate cyclase activity in several somatic cell
systems, prevents spontaneous meiotic maturation of denuded mouse oocytes (ED50 of …

Bovine oocytes are arrested at the prophase of first meiotic cell cycle. Meiosis resumes in
oocytes of pre‐ovulatory follicles upon LH surge. However, oocytes from secondary follicles …

Freshly ovulated (12 hr post hCG) F1 (C57BL 6× CBA) hybrid mouse oocytes were
parthenogenetically activated by repetitive elevation of Ca 2+ induced by carefully controlled …