Multidimensional controllable fabrication of tumor spheroids based on a microfluidic device
Y Hou, Y Zheng, X Zheng, Y Sun, X Yi, Z Wu, JM Lin - Lab on a Chip, 2023 - pubs.rsc.org
Multicellular tumor spheroids (MCTSs) are in vitro solid tumor models with physiological
relevance. To achieve robust process control, a MCTS fabrication method that combines cell …
relevance. To achieve robust process control, a MCTS fabrication method that combines cell …
Continuously perfused microbubble array for 3D tumor spheroid model
S Agastin, UBT Giang, Y Geng, LA DeLouise… - …, 2011 - pubs.aip.org
Multi-cellular tumor spheroids (MCTSs) have been established as a 3D physiologically
relevant tumor model for drug testing in cancer research. However, it is difficult to control the …
relevant tumor model for drug testing in cancer research. However, it is difficult to control the …
Gradient-sized control of tumor spheroids on a single chip
Multicellular tumor spheroids are attracting more attention as a physiologically relevant in
vitro tumor model for biomedical research. The size of spheroids is one of the critical …
vitro tumor model for biomedical research. The size of spheroids is one of the critical …
[HTML][HTML] Uniform tumor spheroids on surface-optimized microfluidic biochips for reproducible drug screening and personalized medicine
Spheroids are recognized for resembling the important characteristics of natural tumors in
cancer research. However, the lack of controllability of the spheroid size, form, and density in …
cancer research. However, the lack of controllability of the spheroid size, form, and density in …
Formation of size-controllable tumour spheroids using a microfluidic pillar array (μFPA) device
Spheroids are recognized for replicating the physiological microenvironment of tumours.
However, because of the lack of controllability of the spheroid size, the response to …
However, because of the lack of controllability of the spheroid size, the response to …
[HTML][HTML] Generation of multicellular tumor spheroids with microwell-based agarose scaffolds for drug testing
X Gong, C Lin, J Cheng, J Su, H Zhao, T Liu, X Wen… - PloS one, 2015 - journals.plos.org
Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue,
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …
A novel three-dimensional microfluidic platform for on chip multicellular tumor spheroid formation and culture
The formation of three-dimensional (3D) multicellular cell spheroids such as microspheres
and embryoid bodies has recently gained much attention as a useful cell culture technique …
and embryoid bodies has recently gained much attention as a useful cell culture technique …
Microfluidic formation of coculture tumor spheroids with stromal cells as a novel 3D tumor model for drug testing
Three-dimensional (3D) tumor spheroids offer unprecedented capability for drug screening
because of their unique features such as spatial 3D structure, relevant physiological …
because of their unique features such as spatial 3D structure, relevant physiological …
Mass fabrication of uniform sized 3D tumor spheroid using high-throughput microfluidic system
In vivo tumors develop in a three-dimensional manner and have unique and complex
characteristics. Physico-biochemical barriers on tumors cause drug resistance and limit drug …
characteristics. Physico-biochemical barriers on tumors cause drug resistance and limit drug …
Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing
L Yu, MCW Chen, KC Cheung - Lab on a Chip, 2010 - pubs.rsc.org
Creating multicellular tumor spheroids is critical for characterizing anticancer treatments
since it may provide a better model than monolayer culture of tumor cells. Moreover …
since it may provide a better model than monolayer culture of tumor cells. Moreover …