[HTML][HTML] A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells
AT Kamath, AF Rochat, D Christensen, EM Agger… - PloS one, 2009 - journals.plos.org
Background In the search for more potent and safer tuberculosis vaccines, CAF01 was
identified as a remarkable formulation. Based on cationic liposomes and including a …
identified as a remarkable formulation. Based on cationic liposomes and including a …
[HTML][HTML] Formulation of a mmaA4 Gene Deletion Mutant of Mycobacterium bovis BCG in Cationic Liposomes Significantly Enhances Protection against Tuberculosis
SC Derrick, D Dao, A Yang, K Kolibab, WR Jacobs… - PLoS …, 2012 - journals.plos.org
A new vaccination strategy is urgently needed for improved control of the global tuberculosis
(TB) epidemic. Using a mouse aerosol Mycobacterium tuberculosis challenge model, we …
(TB) epidemic. Using a mouse aerosol Mycobacterium tuberculosis challenge model, we …
[HTML][HTML] Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model
SL Baldwin, VA Reese, SE Larsen, E Beebe… - Plos one, 2021 - journals.plos.org
An estimated 10 million people developed tuberculosis (TB) disease in 2019 which
underscores the need for a vaccine that prevents disease and reduces transmission. The …
underscores the need for a vaccine that prevents disease and reduces transmission. The …
[HTML][HTML] A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human
JT van Dissel, SA Joosten, ST Hoff, D Soonawala… - Vaccine, 2014 - Elsevier
Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6
(H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their …
(H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their …
[HTML][HTML] Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose
C Aagaard, TTKT Hoang, A Izzo, R Billeskov, JL Troudt… - PloS one, 2009 - journals.plos.org
Background Previously we have shown that Ag85B-TB10. 4 is a highly efficient vaccine
against tuberculosis when delivered in a Th1 inducing adjuvant based on cationic …
against tuberculosis when delivered in a Th1 inducing adjuvant based on cationic …
A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice
X Liu, Z Da, Y Wang, H Niu, R Li, H Yu, S He, M Guo… - Vaccine, 2016 - Elsevier
Tuberculosis (TB) is a serious disease around the world, and protein based subunit vaccine
is supposed to be a kind of promising novel vaccine against it. However, there is no effective …
is supposed to be a kind of promising novel vaccine against it. However, there is no effective …
[HTML][HTML] Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model
J Zhao, S Siddiqui, S Shang, Y Bian, S Bagchi, Y He… - Elife, 2015 - elifesciences.org
Group 1 CD1 molecules, CD1a, CD1b and CD1c, present lipid antigens from
Mycobacterium tuberculosis (Mtb) to T cells. Mtb lipid-specific group 1 CD1-restricted T cells …
Mycobacterium tuberculosis (Mtb) to T cells. Mtb lipid-specific group 1 CD1-restricted T cells …
Rationalized design of a mucosal vaccine protects against Mycobacterium tuberculosis challenge in mice
M Ahmed, H Jiao, R Domingo-Gonzalez… - Journal of Leucocyte …, 2017 - academic.oup.com
Pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a leading
cause of global morbidity and mortality. The only licensed TB vaccine, Mycobacterium bovis …
cause of global morbidity and mortality. The only licensed TB vaccine, Mycobacterium bovis …
[HTML][HTML] Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependent protection …
C Counoupas, KC Ferrell, A Ashhurst… - npj Vaccines, 2020 - nature.com
The development of effective vaccines against bacterial lung infections requires the
induction of protective, pathogen-specific immune responses without deleterious …
induction of protective, pathogen-specific immune responses without deleterious …
[HTML][HTML] Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG
Liposomes have been long considered as a vaccine delivery system but this technology
remains to be fully utilized. Here, we describe a novel liposome-based subunit vaccine …
remains to be fully utilized. Here, we describe a novel liposome-based subunit vaccine …