Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name
suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding …

Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …

▪ Abstract Multiple carboxylesterases (EC 3.1. 1.1) play an important role in the hydrolytic
biotransformation of a vast number of structurally diverse drugs. These enzymes are major …

Carboxylesterases (CEs) are traditionally regarded as xenobiotic metabolizing enzymes that
hydrolyze esterified xenobiotics to alcohol and carboxylic acid products. However, there is a …

This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

Carboxylesterases hydrolyze numerous endogenous and foreign compounds with diverse
structures. Humans and rodents express multiple forms of carboxylesterases, which share a …

Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and
produce a rapid and lethal cholinergic crisis. Development of protein-based therapeutics is …

Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …

The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2 …