Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …

Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic
functions. Evidence from experimental and clinical studies increasingly points to a …

Hypoxia is a hallmark of tumors leading to (mal-) adaptive processes, development of
aggressive phenotypes and treatment resistance. Based on underlying mechanisms and …

Recent preclinical studies have suggested that radiotherapy in combination with
antiangiogenic/vasculature targeting agents enhances the therapeutic ratio of ionizing …

It is now well established that most animal solid tumors contain oxygen-deficient hypoxic
cells and that these cells will influence the response of those tumors to radiation. Identifying …

Purpose: When cancer develops in an immunocompetent host it represents the result of a
successful deception of the immune system as to the nature of the danger and the type of …

Hypoxic modification has been the subject of investigations in clinical radiation oncology
since the early 60s. To date, this has not yet resulted in a treatment that has been widely …

Hypoxia exists in every solid tumor and is associated with poor prognosis because of both
local and systemic therapeutic resistance. Recent studies have focused on the interaction …

Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and
resistance to systemic and radiation therapy. The evolutionary dynamics that links specific …