Purpose: Tumour hypoxia causes resistance to treatment and may promote the development
of metastatic disease. The mean fraction of radiobiologically hypoxic cells has been …

Purpose: Most solid tumors contain hypoxic cells, and the amount of tumor hypoxia has
been shown to have a negative impact on the outcome of radiotherapy. The efficacy of …

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

Cancer evolution plays a key role in both the development of tumors and their response to
therapy. Like all evolutionary processes, tumor evolution is shaped by the environment. In …

Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major
contributing factor for failures of anticancer therapies. Because ionizing radiation depends …

Background Environment inside even a small tumor is characterized by total (anoxia) or
partial oxygen deprivation,(hypoxia). It has been shown that radiotherapy and some …

Any tumor could be controlled by radiation therapy if sufficient dose were delivered to all
tumor cells. Although technological advances in physical treatment delivery have been …

In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often
resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced …

Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …