Since the first reports of experimental lens inversion causing changes in lens cell fate in the
1960s, various factors including the mitogens IGF, EGF, PDGF, as well as Wnts, Notch, and …

Fibroblast growth factors (FGFs) play important roles in many aspects of development,
including lens development. The lens is derived from the surface ectoderm and consists of …

In this review I present an analysis of the process of secondary lens epithelial cell
differentiation. My goal is to provide the reader with an understanding of how multiple factors …

The mammalian lens exhibits characteristic antero-posterior patterns of cellular proliferation,
movement and fibre differentiation. Based on our findings that fibroblast growth factor (FGF) …

Early in development, the ocular lens establishes its distinctive architecture, and this is
maintained throughout life as the lens continues to grow. This growth is tightly regulated …

Lens arises from ectoderm situated next to the optic vesicles. By thickening and
invaginating, the ectoderm forms the lens vesicle. Growth factors are key regulators of cell …

The vertebrate lens has a distinct polarity and structure that are regulated by growth factors
resident in the ocular media. Fibroblast growth factors, in concert with other growth factors …

Recently we identified fibroblast growth factor (FGF), which is present in significant amounts
in neural retinas, as a potent inducer of lens fibre differentiation in our epithelial explant …

Members of the fibroblast growth factor (FGF) family induce lens epithelial cells to undergo
cell division and differentiate into fibres; a low dose of FGF can stimulate cell proliferation …

Lens epithelial cells withdraw from the cell cycle to differentiate into secondary fibre cells in
response to vitreal factors. Fibroblast growth factor (FGF) in the vitreous has been shown to …