Both genetic and epigenetic events play an important role in oncogenic processes. This
review discusses the four hypothesis for the origin of neoplastic transformation (mutational …

This paper introduces a series of invited essays on current controversies in basic cancer
research. The initial group of essays focuses on the detection and interpretation of molecular …

Transformation of normal cells that compose the spectrum of tissues and organ systems of
the intact organism is commonly thought to involve a multistep process ultimately reflected in …

In the past few years and with increasing momentum, it is becoming clear that the keys to
understanding normal processes might be found in those genes, collectively termed …

Studies in two areas of biology have pointed to the existence of cellular genes that exhibit an
oncogenic potential after activation. These normal cellular genes, sometimes termed “proto …

A not yet understood phenomenon in carcinogenesis is presented by the enormous species-
specific and age-specific differences in cellular susceptibility to malignant transformation …

This discussion is concerned with the multiplicity of factors that influence the initiation of
neoplasia and its subsequent course. Factors that are not strictly “carcinogenic” may …

Theoretically, the cancerous phenotype of cells can result from epigenetic or biochemical
regulatory changes without alteration of the genotype. Although epigenetic changes may …

Internationally renowned basic and clinical scientists provide an account of our best current
understanding of the genetics of cancer. These authoritative contributors describe in detail …

Publisher Summary This chapter provides a brief overview of the well-established structural
and behavioral features of malignancy. The chapter focuses on the nature of the …