Extremely unusual genetic conditions can reveal normal processes governing physiologic
regulation and metabolism. Children with rare homozygous mutations in the leptin gene and …

Clément K. Leptin and the genetics of obesity. Acta Pædiatr 1999; Suppl 428: 51–7.
Stockholm. ISSN 0803–5326 The discovery of the Ob gene and its product, leptin, is a good …

Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis.
Recent advances in leptin physiology have revealed that the main role of this hormone in …

The discovery of leptin has led to the elucidation of a robust physiologic system that
maintains fat stores at a relatively constant level. Leptin is a peptide hormone secreted by …

The identification of the hormone leptin by Friedman et al (1) in 1994 has proved to be a
seminal observation in biomedical science. The discovery that a circulating protein secreted …

The fundamental biology of leptin and the leptin system is summarised. The hormone is
produced in several organs, but primarily white adipose tissue, and is subject to acute …

Experimental animal studies demonstrate the effects of leptin on appetite, weight gain and
metabolism. The biological effects of leptin in human adults are still to be determined, but …

Obesity is a complex disease which results from the interaction of multiple genes and the
environment. The recently discovered genes for leptin (ob gene) and the leptin receptor …

Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and …

Leptin, a protein containing 167 amino acids, demonstrates structural similarities with
cytokine family and is mainly produced by adipocytes. The leptin receptor (OB-R) is a large …