Turning liabilities into opportunities: Off-target based drug repurposing in cancer

V Palve, Y Liao, LLR Rix, U Rix - Seminars in cancer biology, 2021 - Elsevier
Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …

[HTML][HTML] “Hard” drug repurposing for precision oncology: the missing link?

P Pantziarka, G Bouche, N André - Frontiers in Pharmacology, 2018 - frontiersin.org
Drug repurposing is at the heart of precision oncology. The move from tissue-or cancer-
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …

[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Can drug repurposing accelerate precision oncology?

LJ Schipper, LJ Zeverijn, MJ Garnett, EE Voest - Cancer discovery, 2022 - AACR
Ongoing new insights in the field of cancer diagnostics, genomic profiling, and cancer
behavior have raised the demand for novel, personalized cancer treatments. As the …

[HTML][HTML] Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development

J Stenvang, I Kümler, SB Nygård, DH Smith… - Frontiers in …, 2013 - frontiersin.org
Cancer is a leading cause of mortality worldwide and matters are only set to worsen as its
incidence continues to rise. Traditional approaches to combat cancer include improved …

[HTML][HTML] Drug repurposing for cancer therapy

Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

[HTML][HTML] Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics

JJ Hernandez, M Pryszlak, L Smith, C Yanchus… - Frontiers in …, 2017 - frontiersin.org
The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …

Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy?

P Pantziarka, G Bouche, L Meheus, V Sukhatme… - Future …, 2015 - Taylor & Francis
Many forms of cancer lack efficacious treatments, despite continuing advances in our
understanding of molecular biology, and the development of precisely targeted agents that …

[HTML][HTML] Computer-aided drug repurposing for cancer therapy: approaches and opportunities to challenge anticancer targets

C Mottini, F Napolitano, Z Li, X Gao… - Seminars in cancer biology, 2021 - Elsevier
Despite huge efforts made in academic and pharmaceutical worldwide research, current
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …

[HTML][HTML] Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy

FR Weth, GB Hoggarth, AF Weth, E Paterson… - British Journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …