Turning liabilities into opportunities: Off-target based drug repurposing in cancer
Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …
and significantly improved patient outcomes in many cases. However, as therapies are …
[HTML][HTML] “Hard” drug repurposing for precision oncology: the missing link?
P Pantziarka, G Bouche, N André - Frontiers in Pharmacology, 2018 - frontiersin.org
Drug repurposing is at the heart of precision oncology. The move from tissue-or cancer-
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …
[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
Can drug repurposing accelerate precision oncology?
LJ Schipper, LJ Zeverijn, MJ Garnett, EE Voest - Cancer discovery, 2022 - AACR
Ongoing new insights in the field of cancer diagnostics, genomic profiling, and cancer
behavior have raised the demand for novel, personalized cancer treatments. As the …
behavior have raised the demand for novel, personalized cancer treatments. As the …
[HTML][HTML] Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development
J Stenvang, I Kümler, SB Nygård, DH Smith… - Frontiers in …, 2013 - frontiersin.org
Cancer is a leading cause of mortality worldwide and matters are only set to worsen as its
incidence continues to rise. Traditional approaches to combat cancer include improved …
incidence continues to rise. Traditional approaches to combat cancer include improved …
[HTML][HTML] Drug repurposing for cancer therapy
Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …
health. Despite significant advances in surgical, radiotherapeutic and immunological …
[HTML][HTML] Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics
JJ Hernandez, M Pryszlak, L Smith, C Yanchus… - Frontiers in …, 2017 - frontiersin.org
The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …
an attractive approach that can save significant investments of time and money during drug …
Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy?
P Pantziarka, G Bouche, L Meheus, V Sukhatme… - Future …, 2015 - Taylor & Francis
Many forms of cancer lack efficacious treatments, despite continuing advances in our
understanding of molecular biology, and the development of precisely targeted agents that …
understanding of molecular biology, and the development of precisely targeted agents that …
[HTML][HTML] Computer-aided drug repurposing for cancer therapy: approaches and opportunities to challenge anticancer targets
Despite huge efforts made in academic and pharmaceutical worldwide research, current
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …
[HTML][HTML] Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy
FR Weth, GB Hoggarth, AF Weth, E Paterson… - British Journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …
development have led to a growing interest in repurposing “old” drugs to treat both common …