Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of
global dimension. MDR infections are difficult to treat and frequently associated with high …

Combination antibiotic therapy for Gram-negative sepsis is controversial. The present review
provides a brief summary of the existing knowledge on combination therapy for severe …

The widespread emergence of antibiotic‐resistant gram‐negative organisms has
compromised the utility of current treatment options for severe infections caused by these …

Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …

Introduction: The ongoing crisis and emergence of extensively-drug resistant (XDR) gram-
negative pathogens in the nosocomial setting is worrisome. The limited armamentarium in …

Whether combination antimicrobial therapy is more efficacious than monotherapy for gram-
negative bacteraemia remains controversial. Although there are theoretical advantages to …

Objective: To assess whether a potential benefit with combination antibiotic therapy is
restricted to the most critically ill subset of patients, particularly those with septic shock. Data …

The treatment of infections caused by multidrug-resistant Gram-negative bacteria is
challenging given the limited options for effective therapy. Combination therapy has …

Introduction: Antibiotic combination therapy is often used to improve clinical efficacy in
patients where a given therapy is thought to have limitations when used alone. However, the …

The re-emergence of infection due to multidrug-resistant Gram-negative bacteria in critically
ill patients presents particular challenges to clinicians, given the lack of a pipeline of new …