A series of novel thiazolyl-pyrazoline derivatives containing benzodioxole (C1–C20) have
been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo [d][1, 3] …

The molecular hybridization of thiazole and pyrazoline heterocyclic structures with diverse
activities appears to be an interesting strategy for developing new anticancer compounds …

Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …

Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …

Pyrazoles, thiazoles and fused thiazoles have been reported to possess many biological
activities. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4, 5-dihydro-1 H-pyrazole-1-carbothioamides …

A series of pyrazole derivatives (1e–30e) has been designed and synthesized, and their
biological activities were evaluated for EGFR and HER-2 inhibition and tumor cell …

A series of N-((1, 3-diphenyl-1H-pyrazol-4-yl) methyl) aniline derivatives (5a–8d) have been
designed and synthesized, and their biological activities were also evaluated as potential …

Background In view of wide range of biological activities of oxazole, a new series of oxazole
analogues was synthesized and its chemical structures were confirmed by spectral data …

A series of 2-(benzylthio)-5-aryloxadiazole derivatives have been designed and
synthesized, and their biological activities are also evaluated for EGFR inhibitory activity …

This study deals with design and synthesis of novel benzofuran–pyrazole hybrids as
anticancer agents. Eight compounds were chosen by National Cancer Institute (NCI), USA to …