Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …

We determined in vivo and in vitro pancreatic islet insulin secretion and glucose metabolism
in fetuses with intrauterine growth restriction (IUGR) caused by chronic placental …

Low birth weight is an important risk factor for impaired glucose tolerance and diabetes later
in life. One hypothesis is that fetal β-cells inherit a persistent defect as a developmental …

Fetal adverse environment, such as insufficient maternal nutrition, placental insufficiency
and stress, alters organ development and leads to poor fetal growth, also called intrauterine …

Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal
models of IUGR. Several underlying mechanisms have been implicated, including …

Being born small due to poor growth before birth increases the risk of developing metabolic
disease, including type 2 diabetes, in later life. Inadequate insulin secretion and decreasing …

Human fetuses with severe intrauterine growth restriction (IUGR) have less pancreatic
endocrine tissue and exhibit β-cell dysfunction, which may limit β-cell function in later life …

Glucose intolerance in adults born with intrauterine growth retardation (IUGR) may involve
peripheral insulin resistance and/or abnormal endocrine pancreas development during fetal …

Placental insufficiency results in intrauterine growth restriction (IUGR), impaired fetal insulin
secretion and less fetal pancreatic β-cell mass, partly due to lower β-cell proliferation rates …

Intrauterine growth restriction (IUGR) is a common complication of pregnancy and increases
the risk of the offspring developing type 2 diabetes mellitus (T2DM) later in life. Alterations in …