Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect

K Kashfi, Y Rayyan, LL Qiao, JL Williams, J Chen… - … of Pharmacology and …, 2002 - ASPET
The novel nitric oxide (NO)-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs),
which are safer than their NSAID counterparts, inhibit the growth of colon cancer cells with …

Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs …

JL Williams, S Borgo, I Hasan, E Castillo, F Traganos… - Cancer Research, 2001 - AACR
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …

Nitric-oxide-donating NSAIDs as agents for cancer prevention

B Rigas, K Kashfi - Trends in Molecular Medicine, 2004 - cell.com
Nitric-oxide-donating nonsteroidal anti-inflammatory drugs (NO–NSAIDs), which consist of
an NSAID with an NO-donating moiety covalently attached to it, promise to contribute …

Evaluation of the antitumoral potential of different nitric oxide-donating non-steroidal anti-inflammatory drugs (NO-NSAIDs) on human urological tumor cell lines

S Huguenin, F Vacherot, J Fleury-Feith, JP Riffaud… - Cancer letters, 2005 - Elsevier
Our work aimed at identifying the antitumoral potential of new nitric oxide (NO)-releasing
non-steroidal anti-inflammatory drug (NSAID) derivatives on human prostate and bladder …

Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation

TR Hundley, B Rigas - Journal of Pharmacology and Experimental …, 2006 - ASPET
Nitric oxide-donating aspirin (NO-aspirin), representing a new concept in the development of
more efficacious nonsteroidal anti-inflammatory drugs, consists of traditional aspirin bearing …

[HTML][HTML] In vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines

A Tesei, P Ulivi, F Fabbri, M Rosetti, C Leonetti… - Journal of Translational …, 2005 - Springer
Background Nitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are
reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the …

Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

CV Rao, BS Reddy, VE Steele, CX Wang, X Liu… - Molecular cancer …, 2006 - AACR
Nitric oxide–releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising
chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable …

A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro

P Andrews, X Zhao, J Allen, F Li, M Chang - Cancer chemotherapy and …, 2008 - Springer
Purpose Previously, we reported in vitro observations suggesting that ibuprofen is an
effective non-prescription non-steroidal anti-inflammatory drug (NSAID) to reduce the …

Novel agents for cancer prevention based on nitric oxide

B Rigas - Biochemical Society Transactions, 2007 - portlandpress.com
NO (nitric oxide) biology has provided the impetus for the development of anticancer agents
based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti …

Efficacy of a nitric oxide–releasing nonsteroidal anti-inflammatory drug and cytotoxic drugs in human colon cancer cell lines in vitro and xenografts

C Leonetti, M Scarsella, G Zupi, W Zoli… - Molecular cancer …, 2006 - AACR
We previously showed that NCX 4040 inhibits in vitro and in vivo tumor growth and induces
apoptosis in human colon cancer cell lines. On the basis of these results, NCX 4040 …