Blood glucose concentration is controlled by a number of hormone and neurotransmitter
signals, either increasing or reducing glucose levels in the case of hypoglycemia or …

Diabetes Mellitus is by far one of the most propagated chronic diseases, affecting 150
million people worldwide. This affliction is caused by a malfunction of pancreatic endocrine …

Objective Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its
hyperglycemic effect helps to restore normal blood glucose. Insulin and somatostatin (SST) …

The pattern of insulin release is crucial for regulation of glucose and lipid haemostasis.
Deficient insulin release causes hyperglycemia and diabetes, whereas excessive insulin …

Blood glucose levels are sensed and controlled by the release of hormones from the islets of
Langerhans in the pancreas. The β-cell, the insulin-secreting cell in the islet, can detect …

Pancreatic islet cells, and in particular insulin-producing beta cells, are centrally involved in
the pathogenesis of diabetes mellitus. These cells are of paramount importance for the …

Insulin secretagogues including sulfonylureas, glinides and incretin‐related drugs such as
dipeptidyl peptidase 4 (DPP‐4) inhibitors and glucagon‐like peptide‐1 receptor agonists are …

Aims To understand better the control of insulin secretion by human β cells and to identify
similarities to and differences from rodent models. Methods Dynamic insulin secretion was …

The sulphonylurea receptor (SUR) subunits of KATP channels are the targets for several
classes of therapeutic drugs. Sulphonylureas close KATP channels in pancreatic β-cells and …

Sulphonylureas have been used for over 50 years to enhance insulin secretion in patients
with Type II (non-insulin-dependent) diabetes mellitus but their therapeutic target was not …