Risk factors for pancreatic cancer: underlying mechanisms and potential targets

T Kolodecik, C Shugrue, M Ashat… - Frontiers in physiology, 2014 - frontiersin.org
Purpose of the review: Pancreatic cancer is extremely aggressive, forming highly chemo-
resistant tumors, and has one of the worst prognoses. The evolution of this cancer is multi …

Pancreatitis as a risk for pancreatic cancer

DC Whitcomb, K Pogue-Geile - Gastroenterology Clinics, 2002 - gastro.theclinics.com
It is time to change the way we think about pancreatic cancer. Only a few years ago, this
cancer epitomized the depths of mystery, ignorance, and hopelessness that cynics of cancer …

Inflammation to cancer: The molecular biology in the pancreas

S Ling, T Feng, K Ji, YU Tian, Y Li - Oncology letters, 2014 - spandidos-publications.com
Inflammatory responses are known to be correlated with cancer initiation and progression,
and exploration of the route from inflammation to cancer makes a great contribution in …

Inflammation and pancreatic cancer: An updated review

K Shadhu, C Xi - Saudi Journal of Gastroenterology, 2019 - journals.lww.com
Pancreatic cancer is a devastating disease with poor prognosis in the modern era.
Inflammatory processes have emerged as key mediators of pancreatic cancer development …

Inflammation and pancreatic cancer: an evidence-based review

JB Greer, DC Whitcomb - Current opinion in pharmacology, 2009 - Elsevier
There is a growing awareness that inflammation plays a contributory role in numerous
pathologies, including pancreatic carcinogenesis. Inflammatory states are characterized by …

[HTML][HTML] Discovering the route from inflammation to pancreatic cancer

N Momi, S Kaur, SR Krishn, SK Batra - Minerva gastroenterologica …, 2012 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) remains a complex malignancy with the worst prognosis, lack of
early diagnostic symptoms and resistance to conventional chemo-and radiotherapies. A …

Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between

N Jura, H Archer, D Bar-Sagi - Cell research, 2005 - nature.com
Pancreatic cancer is a challenging disease for patients, doctors and researchers who for
decades have searched for a cure for this deadly malignancy. Although existing mouse …

Role of inflammation in pancreatic carcinogenesis and the implications for future therapy

G Garcea, AR Dennison, WP Steward, DP Berry - Pancreatology, 2005 - karger.com
Background: The link between inflammation and pancreatic cancer has been observed for a
number of gastrointestinal neoplasms. This review examines the role of inflammation in …

Chronic pancreatitis and the development of pancreatic cancer

HK Kandikattu, SU Venkateshaiah… - Endocrine, Metabolic & …, 2020 - ingentaconnect.com
Pancreatitis is a fibro-inflammatory disorder of the pancreas that can occur acutely or
chronically as a result of the activation of digestive enzymes that damage pancreatic cells …

Pancreatic cancer: pathogenesis, prevention and treatment

FH Sarkar, S Banerjee, Y Li - Toxicology and applied pharmacology, 2007 - Elsevier
Pancreatic cancer is the fourth leading cause of cancer death in the United States with a
very low survival rate of 5 years. To better design new preventive and/or therapeutic …