Purpose The aim of this study was to investigate the diagnostic and prognostic significance
of the methylation status of secreted frizzled-related protein 2 (SFRP2) in colorectal cancer …

AIM: To investigate the functions of promoter hyper-methylation of secreted frizzled-related
proteins (sFRPs) genes in colorectal tumorigenesis and progression. METHODS: The …

Introduction DNA methylation of secreted frizzled-related proteins (SFRPs) can be detected
in colorectal cancer (CRC) tissue, in tissue of adenomas, and in aberrant crypt foci, whereas …

Background: To setup a non-invasive genetic screening method for colorectal cancer, we
evaluated the promoter methylation status of secreted frizzled-related protein1 (sfrp1) in …

Background: Colorectal cancer is one of the five most common cancers in China, and its
incidence is steadily increasing. An accurate and non-invasive screening method is needed …

AIM: To investigate the feasibility of detecting hypermethylated secreted frizzled-related
protein 2 (SFRP2) gene in fecal DNA as a non-invasive screening tool for colorectal cancer …

The role of secreted frizzled-related protein (SFRP) genes in gastric cancer remains largely
unknown. We determined the frequency and functional significance of SFRPs …

DNA methylation is a key mechanism of colorectal carcinogenesis. Analysis of aberrantly
methylation in stool DNA might provide a novel strategy for noninvasive detection of …

BACKGROUND. The secreted frizzled‐related protein 1 gene (SFRP1) encodes a Wnt/β‐
catenin signaling antagonist and frequently is inactivated by promoter methylation in many …

Hypermethylation of secreted frizzled‐related proteins (SFRP) genes frequently occurs with
several cancers but has not been studied in esophageal adenocarcinoma or its precursor …