Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
JM Mulcahy Levy, A Thorburn - Cell Death & Differentiation, 2020 - nature.com
Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting
in basal or stress-induced turnover of cell components that provide energy and …
in basal or stress-induced turnover of cell components that provide energy and …
Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations
CG Towers, D Wodetzki, A Thorburn - Journal of Cell Biology, 2019 - rupress.org
Autophagy is intricately linked with many intracellular signaling pathways, particularly
nutrient-sensing mechanisms and cell death signaling cascades. In cancer, the roles of …
nutrient-sensing mechanisms and cell death signaling cascades. In cancer, the roles of …
Autophagy as a therapeutic target in cancer
N Chen, V Karantza - Cancer biology & therapy, 2011 - Taylor & Francis
Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …
The double-edged sword of autophagy modulation in cancer
E White, RS DiPaola - Clinical cancer research, 2009 - AACR
Macroautophagy (autophagy) is a lysosomal degradation pathway for the breakdown of
intracellular proteins and organelles. Although constitutive autophagy is a homeostatic …
intracellular proteins and organelles. Although constitutive autophagy is a homeostatic …
Autophagy: an emerging target for cancer therapy
M Høyer-Hansen, M Jäättelä - Autophagy, 2008 - Taylor & Francis
Macroautophagy (hereafter referred to as autophagy) is a lysosomal catabolic pathway
whereby cells recycle macromolecules and organelles. The capacity of autophagy to …
whereby cells recycle macromolecules and organelles. The capacity of autophagy to …
The dynamic nature of autophagy in cancer
AC Kimmelman - Genes & development, 2011 - genesdev.cshlp.org
Macroautophagy (referred to hereafter as autophagy) is a highly regulated cellular process
that serves to remove damaged proteins and organelles from the cell. Autophagy contributes …
that serves to remove damaged proteins and organelles from the cell. Autophagy contributes …
Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
Autophagy—A double‐edged sword in oncology
A Apel, H Zentgraf, MW Büchler… - International journal of …, 2009 - Wiley Online Library
Autophagy or “self‐eating” digests proteins and functionless cell organelles to reuse. This
cell‐own recycling system attracts much attention in tumour biology. One of the major …
cell‐own recycling system attracts much attention in tumour biology. One of the major …
Autophagy: cancer's friend or foe?
The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …
controversial. Autophagy can promote tumor suppression during cancer initiation and …
Understanding autophagy in cell death control
F Platini, R Perez-Tomas, S Ambrosio… - Current …, 2010 - ingentaconnect.com
Autophagy is an evolutionarily conserved degradation pathway which primary functions as a
cell survival adaptive mechanism during stress conditions. Autophagy is a tumor suppressor …
cell survival adaptive mechanism during stress conditions. Autophagy is a tumor suppressor …