Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

JM Mulcahy Levy, A Thorburn - Cell Death & Differentiation, 2020 - nature.com
Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting
in basal or stress-induced turnover of cell components that provide energy and …

Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations

CG Towers, D Wodetzki, A Thorburn - Journal of Cell Biology, 2019 - rupress.org
Autophagy is intricately linked with many intracellular signaling pathways, particularly
nutrient-sensing mechanisms and cell death signaling cascades. In cancer, the roles of …

Autophagy as a therapeutic target in cancer

N Chen, V Karantza - Cancer biology & therapy, 2011 - Taylor & Francis
Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …

The double-edged sword of autophagy modulation in cancer

E White, RS DiPaola - Clinical cancer research, 2009 - AACR
Macroautophagy (autophagy) is a lysosomal degradation pathway for the breakdown of
intracellular proteins and organelles. Although constitutive autophagy is a homeostatic …

Autophagy: an emerging target for cancer therapy

M Høyer-Hansen, M Jäättelä - Autophagy, 2008 - Taylor & Francis
Macroautophagy (hereafter referred to as autophagy) is a lysosomal catabolic pathway
whereby cells recycle macromolecules and organelles. The capacity of autophagy to …

The dynamic nature of autophagy in cancer

AC Kimmelman - Genes & development, 2011 - genesdev.cshlp.org
Macroautophagy (referred to hereafter as autophagy) is a highly regulated cellular process
that serves to remove damaged proteins and organelles from the cell. Autophagy contributes …

Autophagy and autophagy-related pathways in cancer

J Debnath, N Gammoh, KM Ryan - Nature reviews Molecular cell …, 2023 - nature.com
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy—A double‐edged sword in oncology

A Apel, H Zentgraf, MW Büchler… - International journal of …, 2009 - Wiley Online Library
Autophagy or “self‐eating” digests proteins and functionless cell organelles to reuse. This
cell‐own recycling system attracts much attention in tumour biology. One of the major …

Autophagy: cancer's friend or foe?

SK Bhutia, S Mukhopadhyay, N Sinha, DN Das… - Advances in cancer …, 2013 - Elsevier
The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …

Understanding autophagy in cell death control

F Platini, R Perez-Tomas, S Ambrosio… - Current …, 2010 - ingentaconnect.com
Autophagy is an evolutionarily conserved degradation pathway which primary functions as a
cell survival adaptive mechanism during stress conditions. Autophagy is a tumor suppressor …