Opportunistic sampling of roadkill as an entry point to accessing natural products assembled by bacteria associated with non-anthropoidal mammalian microbiomes
JL Motley, BW Stamps, CA Mitchell… - Journal of natural …, 2017 - ACS Publications
Few secondary metabolites have been reported from mammalian microbiome bacteria
despite the large numbers of diverse taxa that inhabit warm-blooded higher vertebrates. As …
despite the large numbers of diverse taxa that inhabit warm-blooded higher vertebrates. As …
Extreme environments: microbiology leading to specialized metabolites
The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and
overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the …
overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the …
Approaches to capturing and designing biologically active small molecules produced by uncultured microbes
J Piel - Annual review of microbiology, 2011 - annualreviews.org
Bacteria are one of the most important sources of bioactive natural products for drug
discovery. Yet, in most habitats only a small percentage of all existing prokaryotes is …
discovery. Yet, in most habitats only a small percentage of all existing prokaryotes is …
Novel sources of bioactive molecules: Gut microbiome of species routinely exposed to microorganisms
R Siddiqui, M Soopramanien, AM Alharbi… - Veterinary …, 2022 - mdpi.com
Simple Summary The majority of antibiotics available in the market are produced by bacteria
isolated from soil. However, the low-hanging fruit has been picked; hence, there is a need to …
isolated from soil. However, the low-hanging fruit has been picked; hence, there is a need to …
Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products
LM Sanchez, WR Wong, RM Riener, CJ Schulze… - PloS one, 2012 - journals.plos.org
Historically, marine invertebrates have been a prolific source of unique natural products,
with a diverse array of biological activities. Recent studies of invertebrate-associated …
with a diverse array of biological activities. Recent studies of invertebrate-associated …
Natural product discovery from the human microbiome
MR Wilson, L Zha, EP Balskus - Journal of Biological Chemistry, 2017 - ASBMB
Human-associated microorganisms have the potential to biosynthesize numerous
secondary metabolites that may mediate important host-microbe and microbe-microbe …
secondary metabolites that may mediate important host-microbe and microbe-microbe …
Leveraging a large microbial strain collection for natural product discovery
Throughout history, natural products have significantly contributed to the discovery of novel
chemistry, drug leads, and tool molecules to probe and address complex challenges in …
chemistry, drug leads, and tool molecules to probe and address complex challenges in …
Bioactive natural products from novel microbial sources
VL Challinor, HB Bode - Annals of the New York Academy of …, 2015 - Wiley Online Library
Despite the importance of microbial natural products for human health, only a few bacterial
genera have been mined for the new natural products needed to overcome the urgent threat …
genera have been mined for the new natural products needed to overcome the urgent threat …
Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts)
AB Narrowe, JMS Lemons, KK Mahalak… - Frontiers in Cellular …, 2024 - frontiersin.org
The genus Senna contains globally distributed plant species of which the leaves, roots, and
seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds …
seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds …
[PDF][PDF] Accessing bioactive natural products from the human microbiome
A Milshteyn, DA Colosimo, SF Brady - Cell host & microbe, 2018 - cell.com
Natural products have long played a pivotal role in the development of therapeutics for a
variety of diseases. Traditionally, soil and marine environments have provided a rich …
variety of diseases. Traditionally, soil and marine environments have provided a rich …