Opportunistic sampling of roadkill as an entry point to accessing natural products assembled by bacteria associated with non-anthropoidal mammalian microbiomes

JL Motley, BW Stamps, CA Mitchell… - Journal of natural …, 2017 - ACS Publications
Few secondary metabolites have been reported from mammalian microbiome bacteria
despite the large numbers of diverse taxa that inhabit warm-blooded higher vertebrates. As …

Extreme environments: microbiology leading to specialized metabolites

AM Sayed, MHA Hassan, HA Alhadrami… - Journal of applied …, 2020 - academic.oup.com
The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and
overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the …

Approaches to capturing and designing biologically active small molecules produced by uncultured microbes

J Piel - Annual review of microbiology, 2011 - annualreviews.org
Bacteria are one of the most important sources of bioactive natural products for drug
discovery. Yet, in most habitats only a small percentage of all existing prokaryotes is …

Novel sources of bioactive molecules: Gut microbiome of species routinely exposed to microorganisms

R Siddiqui, M Soopramanien, AM Alharbi… - Veterinary …, 2022 - mdpi.com
Simple Summary The majority of antibiotics available in the market are produced by bacteria
isolated from soil. However, the low-hanging fruit has been picked; hence, there is a need to …

Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products

LM Sanchez, WR Wong, RM Riener, CJ Schulze… - PloS one, 2012 - journals.plos.org
Historically, marine invertebrates have been a prolific source of unique natural products,
with a diverse array of biological activities. Recent studies of invertebrate-associated …

Natural product discovery from the human microbiome

MR Wilson, L Zha, EP Balskus - Journal of Biological Chemistry, 2017 - ASBMB
Human-associated microorganisms have the potential to biosynthesize numerous
secondary metabolites that may mediate important host-microbe and microbe-microbe …

Leveraging a large microbial strain collection for natural product discovery

AD Steele, CN Teijaro, D Yang, B Shen - Journal of Biological Chemistry, 2019 - ASBMB
Throughout history, natural products have significantly contributed to the discovery of novel
chemistry, drug leads, and tool molecules to probe and address complex challenges in …

Bioactive natural products from novel microbial sources

VL Challinor, HB Bode - Annals of the New York Academy of …, 2015 - Wiley Online Library
Despite the importance of microbial natural products for human health, only a few bacterial
genera have been mined for the new natural products needed to overcome the urgent threat …

Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts)

AB Narrowe, JMS Lemons, KK Mahalak… - Frontiers in Cellular …, 2024 - frontiersin.org
The genus Senna contains globally distributed plant species of which the leaves, roots, and
seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds …

[PDF][PDF] Accessing bioactive natural products from the human microbiome

A Milshteyn, DA Colosimo, SF Brady - Cell host & microbe, 2018 - cell.com
Natural products have long played a pivotal role in the development of therapeutics for a
variety of diseases. Traditionally, soil and marine environments have provided a rich …