Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia
E San José-Eneriz, X Agirre, A Jiménez-Velasco… - European journal of …, 2009 - Elsevier
BACKGROUND: Expression of the pro-apoptotic BCL-2-interacting mediator (BIM) has
recently been implicated in imatinib-induced apoptosis of BCR-ABL1+ cells. However, the …
recently been implicated in imatinib-induced apoptosis of BCR-ABL1+ cells. However, the …
Low-level expression of proapoptotic Bcl-2–interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of …
KJ Aichberger, M Mayerhofer, MT Krauth, A Vales… - Cancer research, 2005 - AACR
Chronic myeloid leukemia (CML) is a myeloproliferative disease in which BCR/ABL
enhances survival of leukemic cells through modulation of proapoptotic and antiapoptotic …
enhances survival of leukemic cells through modulation of proapoptotic and antiapoptotic …
Imatinib and nilotinib induce apoptosis of chronic myeloid leukemia cells through a Bim-dependant pathway modulated by cytokines
F Belloc, F Moreau-Gaudry, M Uhalde… - Cancer biology & …, 2007 - Taylor & Francis
It is an important challenge to better understand the mechanisms of tyrosine kinase
inhibitors-induced apoptosis in CML cells. Thus, we have investigated how this apoptosis …
inhibitors-induced apoptosis in CML cells. Thus, we have investigated how this apoptosis …
[HTML][HTML] A single nucleotide polymorphism in cBIM is associated with a slower achievement of major molecular response in chronic myeloid leukaemia treated with …
V Augis, K Airiau, M Josselin, B Turcq, FX Mahon… - PLoS …, 2013 - journals.plos.org
Purpose BIM is essential for the response to tyrosine-kinase inhibitors (TKI) in chronic
myeloid leukaemia (CML) patients. Recently, a deletion polymorphism in intron 2 of the BIM …
myeloid leukaemia (CML) patients. Recently, a deletion polymorphism in intron 2 of the BIM …
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
J Kuroda, H Puthalakath, MS Cragg… - Proceedings of the …, 2006 - National Acad Sciences
Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl+ leukemias.
We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated …
We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated …
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia
A Paterson, CI Mockridge, JE Adams… - Blood, The Journal …, 2012 - ashpublications.org
B-cell receptor and microenvironment-derived signals promote accumulation of chronic
lymphocytic leukemia (CLL) cells through increased proliferation and/or decreased …
lymphocytic leukemia (CLL) cells through increased proliferation and/or decreased …
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors
R Kuribara, H Honda, H Matsui, T Shinjyo… - … and cellular biology, 2004 - Am Soc Microbiol
Bcr-Abl kinase is known to reverse apoptosis of cytokine-dependent cells due to cytokine
deprivation, although it has been controversial whether chronic myeloid leukemia (CML) …
deprivation, although it has been controversial whether chronic myeloid leukemia (CML) …
BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia
J Bhattacharyya, K Mihara, S Yasunaga, H Tanaka… - Annals of …, 2009 - Springer
BMI-1 plays a critical role in regulating the activity of hematopoietic stem and progenitor
cells. Patients with chronic myeloid leukemia (CML) are at a risk of developing blastic crisis …
cells. Patients with chronic myeloid leukemia (CML) are at a risk of developing blastic crisis …
[HTML][HTML] ABT-737 increases tyrosine kinase inhibitor–induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34+ CD38 …
K Airiau, FX Mahon, M Josselin, M Jeanneteau… - Experimental …, 2012 - Elsevier
Chronic myeloid leukemia (CML) tumorigenicity is driven by the oncogenic BCR-ABL
tyrosine kinase. Specific tyrosine kinase inhibitors (TKI) have been designed and are now …
tyrosine kinase. Specific tyrosine kinase inhibitors (TKI) have been designed and are now …
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
F Luciano, A Jacquel, P Colosetti, M Herrant, S Cagnol… - Oncogene, 2003 - nature.com
Bim is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this
family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same …
family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same …