Propagating wave of ERK activation orients collective cell migration
The biophysical framework of collective cell migration has been extensively investigated in
recent years; however, it remains elusive how chemical inputs from neighboring cells are …
recent years; however, it remains elusive how chemical inputs from neighboring cells are …
ERK-mediated mechanochemical waves direct collective cell polarization
During collective migration of epithelial cells, the migration direction is aligned over a tissue-
scale expanse. Although the collective cell migration is known to be directed by mechanical …
scale expanse. Although the collective cell migration is known to be directed by mechanical …
A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration
Upon the initiation of collective cell migration, the cells at the free edge are specified as
leader cells; however, the mechanism underlying the leader cell specification remains …
leader cells; however, the mechanism underlying the leader cell specification remains …
[HTML][HTML] Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K
N Yamaguchi, T Mizutani, K Kawabata, H Haga - Scientific reports, 2015 - nature.com
Collective cell migration plays a crucial role in several biological processes, such as
embryonic development, wound healing and cancer metastasis. Here, we focused on …
embryonic development, wound healing and cancer metastasis. Here, we focused on …
Theory of mechanochemical patterning and optimal migration in cell monolayers
Collective cell migration offers a rich field of study for non-equilibrium physics and cellular
biology, revealing phenomena such as glassy dynamics, pattern formation and active …
biology, revealing phenomena such as glassy dynamics, pattern formation and active …
Role of boundary conditions in an experimental model of epithelial wound healing
DL Nikolic, AN Boettiger, D Bar-Sagi… - … of physiology-cell …, 2006 - journals.physiology.org
Coordinated cell movements in epithelial layers are essential for proper tissue
morphogenesis and homeostasis, but our understanding of the mechanisms that coordinate …
morphogenesis and homeostasis, but our understanding of the mechanisms that coordinate …
Mechanisms of collective cell migration at a glance
O Ilina, P Friedl - Journal of cell science, 2009 - journals.biologists.com
Collective cell movement occurs when two or more cells that retain their cell-cell junctions
move together across a two-dimensional (2D) layer of extracellular matrix (ECM) or through …
move together across a two-dimensional (2D) layer of extracellular matrix (ECM) or through …
Collective cell migration in development
CJ Weijer - Journal of cell science, 2009 - journals.biologists.com
Collective cell migration is a key process during the development of most organisms. It can
involve either the migration of closely packed mesenchymal cells that make dynamic …
involve either the migration of closely packed mesenchymal cells that make dynamic …
[HTML][HTML] Live visualization of ERK activity in the mouse blastocyst reveals lineage-specific signaling dynamics
FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that
comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly …
comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly …
Excitable signal transduction networks in directed cell migration
PN Devreotes, S Bhattacharya… - Annual review of cell …, 2017 - annualreviews.org
Although directed migration of eukaryotic cells may have evolved to escape nutrient
depletion, it has been adopted for an extensive range of physiological events during …
depletion, it has been adopted for an extensive range of physiological events during …