[HTML][HTML] Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer's disease model
LC Schmid, M Mittag, S Poll, J Steffen, J Wagner… - Neuron, 2016 - cell.com
Alzheimer's disease (AD) is characterized by cognitive decline and neuronal network
dysfunction, but the underlying mechanisms remain unknown. In the hippocampus …
dysfunction, but the underlying mechanisms remain unknown. In the hippocampus …
[HTML][HTML] Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease
Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
decline. These impairments correlate with early alterations in neuronal network activity in AD …
decline. These impairments correlate with early alterations in neuronal network activity in AD …
Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1× APP transgenic model of Alzheimer's disease
B Ramos, D Baglietto-Vargas, JC del Rio… - Neurobiology of …, 2006 - Elsevier
At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal
loss. However, the early neurodegenerative deficiencies have not been yet identified. Here …
loss. However, the early neurodegenerative deficiencies have not been yet identified. Here …
[HTML][HTML] Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β …
Accumulation of amyloid β oligomers (AβO) in Alzheimer's disease (AD) impairs
hippocampal theta and gamma oscillations. These oscillations are important in memory …
hippocampal theta and gamma oscillations. These oscillations are important in memory …
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Alzheimer's disease is the most frequent neurodegenerative disorder and the most common
cause of dementia in the elderly. Diverse lines of evidence suggest that amyloid-β (Aβ) …
cause of dementia in the elderly. Diverse lines of evidence suggest that amyloid-β (Aβ) …
[HTML][HTML] Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease
S Hijazi, TS Heistek, P Scheltens, U Neumann… - Molecular …, 2020 - nature.com
Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …
[HTML][HTML] Hippocampal somatostatin interneurons, long-term synaptic plasticity and memory
A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons.
These complex inhibitory interconnections largely contribute to the tight modulation of …
These complex inhibitory interconnections largely contribute to the tight modulation of …
[HTML][HTML] GABAergic inhibitory interneuron deficits in Alzheimer's disease: implications for treatment
Y Xu, M Zhao, Y Han, H Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
[HTML][HTML] Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer's disease
Background Alzheimer's disease (AD) is characterized by amyloid deposition, tangle
formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of …
formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of …
[HTML][HTML] Phenotypic alterations in hippocampal NPY-and PV-expressing interneurons in a presymptomatic transgenic mouse model of Alzheimer's disease
I Mahar, MS Albuquerque… - Frontiers in Aging …, 2017 - frontiersin.org
Interneurons, key regulators of hippocampal neuronal network excitability and
synchronization, are lost in advanced stages of Alzheimer's disease (AD). Given that …
synchronization, are lost in advanced stages of Alzheimer's disease (AD). Given that …
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