Background: Glucocorticoid-resistant bronchial asthma is characterized by failure of
corticosteroids to suppress key asthma-relevant, cell–mediated inflammatory responses in …

SUMMARY A total of 37chronic, severe, nonsmoking asthmatic patients with documented
reversible airways obstruction were classified as glucocorticoid-sensitive or-resistant on the …

Glucocorticoids are highly effective in the control of asthma and other chronic inflammatory
or immune diseases. The value of steroids in asthma became apparent soon after the …

We stimulated peripheral blood mononuclear cells from 14 healthy subjects, 14 patients with
stable asthma, and 13 patients with unstable asthma with interleukin (IL)-2 and IL-4 to …

Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Glucocorticoid (GC)-insensitive asthma is a challenging clinical problem that can be
associated with life-threatening disease progression. The molecular basis of GC insensitivity …

BACKGROUND: Glucocorticoids are important medications used to control the airway
inflammation associated with asthma. Synthetic glucocorticoids vary in their binding affinity …

Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

Recent studies indicate that chronic asthma is associated with a spectrum of glucocorticoid
receptor (GCR) binding abnormalities that are cytokine-inducible. These GCR abnormalities …