Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy

C Liu, X Yan, Y Zhang, M Yang, Y Ma, Y Zhang… - Journal of …, 2022 - Springer
Background Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by
diffuse inflammation of the colonic mucosa and a relapsing and remitting course. The current …

[HTML][HTML] Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis

C Gao, Y Zhou, Z Chen, H Li, Y Xiao, W Hao, Y Zhu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Abstract Rationale: Ulcerative colitis (UC), a typical kind of inflammatory bowel disease
(IBD), is an idiopathic chronic intestinal inflammation. Conventional therapeutic strategies …

Edible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis via facilitating double-positive CD4+CD8+T cells expansion

M Zhu, H Xu, Y Liang, J Xu, N Yue, Y Zhang… - Journal of …, 2023 - Springer
Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the
treatment of ulcerative colitis (UC). As a proof of concept, we isolated and identified …

Garlic-derived exosome-like nanovesicles alleviate dextran sulphate sodium-induced mouse colitis via the TLR4/MyD88/NF-κB pathway and gut microbiota …

Z Zhu, L Liao, M Gao, Q Liu - Food & function, 2023 - pubs.rsc.org
Plant-derived exosome-like nanovesicles play an important role in transferring their
biological cargos to recipient cells. The effect of garlic-derived exosome-like nanovesicles …

[HTML][HTML] Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine

T Sun, CHT Kwong, C Gao, J Wei, L Yue, J Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is featured with relapsing inflammation in the colon, where
macrophages are recruited and polarized locally into M1 type to drive further inflammation …

“Dual sensitive supramolecular curcumin nanoparticles” in “advanced yeast particles” mediate macrophage reprogramming, ROS scavenging and inflammation …

X Han, R Luo, S Qi, Y Wang, L Dai, W Nie, M Lin… - Journal of …, 2023 - Springer
Ulcerative colitis (UC) faces some barriers in oral therapy, such as how to safely deliver
drugs to the colon and accumulate in the colon lesions. Hence, we report an advanced yeast …

Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit

B Wang, X Zhuang, ZB Deng, H Jiang, J Mu, Q Wang… - Molecular Therapy, 2014 - cell.com
The gut mucosal immune system is considered to play an important role in counteracting
potential adverse effects of food-derived antigens including nanovesicles. Whether …

Anti-inflammatory effects of rosmarinic acid-loaded nanovesicles in acute colitis through modulation of NLRP3 inflammasome

S Marinho, M Illanes, J Ávila-Román, V Motilva… - Biomolecules, 2021 - mdpi.com
Ulcerative colitis (UC), one of the two main types of inflammatory bowel disease, has no
effective treatment. Rosmarinic acid (RA) is a polyphenol that, when administered orally, is …

Biological properties and therapeutic effects of plant-derived nanovesicles

S Di Gioia, MN Hossain, M Conese - Open Medicine, 2020 - degruyter.com
Exosomes-like nanoparticles can be released by a variety of plants and vegetables. The
relevance of plant-derived nanovesicles (PDNVs) in interspecies communication is derived …

[HTML][HTML] Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines

J Kim, S Zhang, Y Zhu, R Wang, J Wang - Journal of Ginseng Research, 2023 - Elsevier
Background Damage to the healthy intestinal epithelial layer and regulation of the intestinal
immune system, closely interrelated, are considered pivotal parts of the curative treatment …