The effects of ruthenium red (RR) on the skeletal and cardiac muscle ryanodine receptors
(RyRs) were studied in vesicle-Ca 2+ flux,[3 H] ryanodine binding, and single channel …

In cardiac muscle, a Ca2+/calmodulin-dependent protein kinase (CaM kinase) associated
with the sarcoplasmic reticulum (SR) is known to phosphorylate the membrane proteins …

Ca 2+ activation of skeletal (RyR1) and cardiac (RyR2) muscle Ca 2+ release channels
(ryanodine receptors) occurs with EC 50 values of about 1 μm. Ca 2+ inactivation occurs …

Ca 2+-dependent inhibition of native and isolated ryanodine receptor (RyR) calcium release
channels from sheep heart and rabbit skeletal muscle was investigated using the lipid …

Ryanodine receptors (RyRs) are the Ca 2+ release channels in the sarcoplasmic reticulum
in striated muscle which play an important role in excitation-contraction coupling and cardiac …

Spontaneous Ca 2+ release occurs in cardiac cells during sarcoplasmic reticulum Ca 2+
overload, a process we refer to as store-overload-induced Ca 2+ release (SOICR). Unlike …

1. In muscle, intracellular calcium concentration, hence skeletal muscle force and cardiac
output, is regulated by uptake and release of calcium from the sarcoplasmic reticulum (SR) …

A rapid assay for high affinity [3 H] ryanodine binding to 3-[(3-cholamidopropyl)
dimethylammonio]-1-propanesulfonic acid (CHAPS)-solubilized recombinant or native Ca …

The single-channel activity of rabbit skeletal muscle ryanodine receptor (skeletal RyR) and
dog cardiac RyR was studied as a function of cytosolic [Ca2+]. The studies reveal that for …

The effects of ruthenium red and the related compounds tetraamine palladium (4APd) and
tetraamine platinum (4APt) were studied on the ryanodine activated Ca2+ release channel …