Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells
S Guo, M Liu, G Wang, M Torroella-Kouri… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Significant correlations between obesity and incidence of various cancers have been
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …
Leptin–cytokine crosstalk in breast cancer
G Newman, RR Gonzalez-Perez - Molecular and cellular endocrinology, 2014 - Elsevier
Despite accumulating evidence suggesting a positive correlation between leptin levels,
obesity, post-menopause and breast cancer incidence, our current knowledge on the …
obesity, post-menopause and breast cancer incidence, our current knowledge on the …
Multifaceted leptin network: the molecular connection between obesity and breast cancer
NK Saxena, D Sharma - Journal of mammary gland biology and neoplasia, 2013 - Springer
High plasma levels of leptin, a major adipocytokine produced by adipocytes, are correlated
with increased fat mass in obese state. Leptin is emerging as a key candidate molecule …
with increased fat mass in obese state. Leptin is emerging as a key candidate molecule …
The multifactorial role of leptin in driving the breast cancer microenvironment
S Ando, S Catalano - Nature reviews endocrinology, 2012 - nature.com
Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …
Leptin signaling in breast cancer: an overview
D Cirillo, AM Rachiglio, R La Montagna… - Journal of cellular …, 2008 - Wiley Online Library
The adipocyte‐derived peptide leptin acts through binding to specific membrane receptors,
of which six isoforms (obRa‐f) have been identified up to now. Binding of leptin to its …
of which six isoforms (obRa‐f) have been identified up to now. Binding of leptin to its …
[HTML][HTML] Cellular and molecular crosstalk between leptin receptor and estrogen receptor-α in breast cancer: molecular basis for a novel therapeutic setting
R Fusco, M Galgani, C Procaccini… - Endocrine-related …, 2010 - erc.bioscientifica.com
Obesity is associated with an increased risk of breast cancer. A number of adipocytokines
are increased in obesity causing low-level chronic inflammation associated with an …
are increased in obesity causing low-level chronic inflammation associated with an …
[HTML][HTML] Leptin and cancer: updated functional roles in carcinogenesis, therapeutic niches, and developments
TC Lin, M Hsiao - International Journal of Molecular Sciences, 2021 - mdpi.com
Leptin is an obesity-associated adipokine that is known to regulate energy metabolism and
reproduction and to control appetite via the leptin receptor. Recent work has identified …
reproduction and to control appetite via the leptin receptor. Recent work has identified …
Obesity and cancer: Focus on leptin
K Ayed, L Nabi, R Akrout, H Mrizak, A Gorrab… - Molecular biology …, 2023 - Springer
Over the past decades, obesity has grown to epidemic proportions worldwide. It has been
associated with an increased risk for different types of cancer. In addition, obesity has been …
associated with an increased risk for different types of cancer. In addition, obesity has been …
Leptin, obesity and breast cancer: progress to understanding the molecular connections
Highlights•Obesity is a pandemic condition associated with both risk and prognosis of breast
cancer.•The adipokine leptin is a plausible molecular link between obesity and breast …
cancer.•The adipokine leptin is a plausible molecular link between obesity and breast …
[HTML][HTML] The multifaceted mechanism of leptin signaling within tumor microenvironment in driving breast cancer growth and progression
Adipokines represent likely candidates to mediate the increased breast cancer risk and the
enhanced progression associated with obesity. Other contributors to obesity-related cancer …
enhanced progression associated with obesity. Other contributors to obesity-related cancer …