Alzheimer's disease (AD) brains contain large numbers of amyloid-β peptide (Aβ) deposits
associated with activated microglia, astrocytes and dystrophic neurites. Activated …

We hypothesize that amyloid (Aβ) peptide-containing neuritic plaques in the brains of
patients with Alzheimer's disease represent chronic inflammatory foci mediated by the …

A hallmark of the immunopathology associated with Alzheimer's disease (AD) is the
presence of activated microglia surrounding senile plaque deposits of β-amyloid (Aβ) …

Increasing evidence points to Aβ-containing senile plaques as primary etiological agents in
Alzheimer's disease (AD). The mechanism by which these deposits cause neurotoxicity is …

J. Neurochem.(2010) 113, 389–401. Abstract Alzheimer's disease (AD), a progressive
neurodegenerative disease characterized by the accumulation of amyloid‐β protein and …

Amyloid β peptide (Aβ) is a major component of senile plaques, one of the principle
pathological features in Alzheimer's disease (AD) brains. Fibrillar Aβ has been shown to …

Recent studies showing that microglia internalize the amyloid β-peptide (Aβ) suggest that
these cells have the potential for clearing Aβ deposits in Alzheimer's disease, and …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Complement activation products C1q, C4c/d, and C3c/d in amyloid plaques in Alzheimer's
disease probably result from direct binding and activation of C1 by amyloid β peptides. RT …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …