Motivation: The binding of endogenous antigenic peptides to MHC class I molecules is an
important step during the immunologic response of a host against a pathogen. Thus, various …

Since determining the crystallographic structure of all peptide‐MHC complexes is infeasible,
an accurate prediction of the conformation is a critical computational problem. These models …

Motivation: Various computational methods have been proposed to tackle the problem of
predicting the peptide binding ability for a specific MHC molecule. These methods are based …

Knowledge of MHC II binding peptides is highly desired in immunological research,
particularly in the context of cancer, autoimmune diseases, or allergies. The most successful …

Background Modelling the interaction between potentially antigenic peptides and Major
Histocompatibility Complex (MHC) molecules is a key step in identifying potential T-cell …

Background MHC class II proteins bind oligopeptide fragments derived from proteolysis of
pathogen antigens, presenting them at the cell surface for recognition by CD4+ T cells …

Designed peptides that bind to major histocompatibility protein I (MHC-I) allomorphs bear
the promise of representing epitopes that stimulate a desired immune response. A rigorous …

Background The binding of peptide fragments of antigens to class II MHC is a crucial step in
initiating a helper T cell immune response. The identification of such peptide epitopes has …

Background: The binding of T-cell antigenic peptides to MHC molecules is a prerequisite for
their immunogenicity. The ability to identify binding peptides based on the protein sequence …

Peptide binding to class I major histocompatibility complex (MHCI) molecules is a key step in
the immune response and the structural details of this interaction are of importance in the …