How to interpret a genome-wide association study
TA Pearson, TA Manolio - Jama, 2008 - jamanetwork.com
Genome-wide association (GWA) studies use high-throughput genotyping technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
Genome-wide association studies: results from the first few years and potential implications for clinical medicine
JN Hirschhorn, ZKZ Gajdos - Annual review of medicine, 2011 - annualreviews.org
Most common diseases and quantitative traits are heritable: determined in part by genetic
variation within the population. The inheritance is typically polygenic in that combined effects …
variation within the population. The inheritance is typically polygenic in that combined effects …
How to use an article about genetic association: B: Are the results of the study valid?
In the first article of this series, we reviewed the basic genetics concepts necessary to
understand genetic association studies. In this second article, we enumerate the major …
understand genetic association studies. In this second article, we enumerate the major …
Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …
disease gene discovery. A substantial number of recent GWAS indicate that for most …
Genome-wide association studies and beyond
JS Witte - Annual review of public health, 2010 - annualreviews.org
Genome-wide association studies (GWAS) provide an important avenue for undertaking an
agnostic evaluation of the association between common genetic variants and risk of …
agnostic evaluation of the association between common genetic variants and risk of …
10 years of GWAS discovery: biology, function, and translation
Application of the experimental design of genome-wide association studies (GWASs) is now
10 years old (young), and here we review the remarkable range of discoveries it has …
10 years old (young), and here we review the remarkable range of discoveries it has …
[PDF][PDF] A short history of the genome-wide association study: where we were and where we are going
S Ikegawa - Genomics & informatics, 2012 - synapse.koreamed.org
Recent rapid advances in genetic research are ushering us into the genome sequence era,
where an individual's genome information is utilized for clinical practice. The most …
where an individual's genome information is utilized for clinical practice. The most …
15 years of genome-wide association studies and no signs of slowing down
RJF Loos - Nature Communications, 2020 - nature.com
Over the past 15 years, genome-wide association studies (GWASs) have generated a
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
Genome-wide association studies (GWAS) have led to a rapid increase in available data on
common genetic variants and phenotypes and numerous discoveries of new loci associated …
common genetic variants and phenotypes and numerous discoveries of new loci associated …