Over the past century, ionizing radiation has been known to induce cataracts in the
crystalline lens of the eye, but its mechanistic underpinnings remain incompletely …

Whilst the cataractogenic potential of ionizing radiation has been known for over the past
120 years, little is known about radiation responses of lens cells. Our previous work was the …

Lens epithelial cell proliferation and differentiation are naturally well regulated and
controlled, a characteristic essential for lens structure, symmetry and function. The effect of …

Cataract is the leading cause of visual impairment which can result in blindness. Cataract
formation has been associated with radiation exposure; however, the mechanistic …

Elevated cataract risk after radiation exposure was established soon after the discovery of X-
rays in 1895. Today, increased cataract incidence among medical imaging practitioners and …

The lens of the eye is one of the most radiosensitive tissues. Although the exact mechanism
of radiation-induced cataract development remains unknown, altered proliferation …

Long duration spaceflight (LDSF) exposes atronauts to radiation including solar particle
events (SPE) and galactic cosmic rays (GCR)(Fig. 1). SPE are released by our Sun and this …

Ionizing radiation is a proven human carcinogen and cataractogen. The crystalline lens of
the eye is among the most radiosensitive tissues in the body. A clouding of the normally …

The knowledge on responses of human lens epithelial cells (HLECs) to ionizing radiation
exposure is important to understand mechanisms of radiation cataracts that are of concern in …

The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …