There is an intimate, yet poorly understood, link between cellular metabolic status, cell
signalling and transcription. Central metabolic pathways are under the control of signalling …

Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

Mammalian cells require growth-factor-receptor-initiated signaling to proliferate. Signal
transduction not only initiates entry into the cell cycle, but also reprograms cellular …

Although nutrient availability is a major driver of cell growth, and continuous adaptation to
nutrient supply is critical for the development and survival of all organisms, the molecular …

Highlights•Metabolites actively participate in regulating cellular metabolism.•Metabolite
intervention is common on all levels of enzyme regulation.•Knowledge of metabolite sensing …

Metabolite sensing is one of the most fundamental biological processes. During evolution,
multilayered mechanisms developed to sense fluctuations in a wide spectrum of …

The investigation of metabolic regulation at the transcriptional level presents different
challenges than those encountered in the study of other important problems like …

There is a growing appreciation that metabolic signals are integrated and coupled to cell
cycle progression. However, the molecular wiring that connects nutrient availability …

It is recognized that cell metabolism is tightly connected to other cellular processes such as
regulation of gene expression. Metabolic pathways not only provide the precursor molecules …

Cell growth is regulated by coordination of both extracellular nutrients and intracellular
metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin …