Subacute and chronic proteomic and phosphoproteomic analyses of a mouse model of traumatic brain injury at two timepoints and comparison with chronic traumatic …

A Morin, R Davis, T Darcey, M Mullan, B Mouzon… - Molecular Brain, 2022 - Springer
Repetitive mild traumatic brain injury (r-mTBI) is the most widespread type of brain trauma
worldwide. The cumulative injury effect triggers long-lasting pathological and molecular …

Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat

DK Wright, RD Brady, A Kamnaksh, J Trezise, M Sun… - Scientific reports, 2019 - nature.com
A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but
repeated mTBI (RmTBI) is associated with cumulative and chronic neurological …

Unbiased proteomic approach identifies unique and coincidental plasma biomarkers in repetitive mTBI and AD pathogenesis

JO Ojo, G Crynen, JM Reed, R Ajoy… - Frontiers in aging …, 2018 - frontiersin.org
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer's
disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or …

Quantitative proteomics reveals the dynamic pathophysiology across different stages in a rat model of severe traumatic brain injury

W Luo, Z Yang, W Zhang, D Zhou, X Guo… - Frontiers in Molecular …, 2022 - frontiersin.org
Background Severe traumatic brain injury (TBI) has become a global health problem and
causes a vast worldwide societal burden. However, distinct mechanisms between acute and …

Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury In vivo

CS Dunn, LA Ferreira, SM Venier, SF Ali… - Neurotrauma …, 2022 - liebertpub.com
The pathological effects of repeated traumatic brain injuries (TBIs) are largely unknown. To
gain a detailed understanding of the cortical tissue acute biological response after one or …

Behavioral, blood and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

DK Wright, J Trezise, A Kamnaksh, R Bekdash… - Scientific reports, 2016 - nature.com
Repeated mild traumatic brain injuries (mTBI) may lead to serious neurological
consequences, especially if re-injury occurs within the period of increased cerebral …

[HTML][HTML] Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: novel insights using a clinically relevant rat model

L Pham, DK Wright, WT O'Brien, J Bain, C Huang… - Neurobiology of …, 2021 - Elsevier
A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological
conditions, however there is still much unknown about the underlying mechanisms. To …

Identification of plasma biomarkers of TBI outcome using proteomic approaches in an APOE mouse model

F Crawford, G Crynen, J Reed, B Mouzon… - Journal of …, 2012 - liebertpub.com
The current lack of diagnostic and prognostic biomarkers for traumatic brain injury (TBI)
confounds treatment and management of patients and is of increasing concern as the TBI …

Early onset senescence and cognitive impairment in a murine model of repeated mTBI

N Schwab, YJ Ju, LN Hazrati - Acta Neuropathologica Communications, 2021 - Springer
Mild traumatic brain injury (mTBI) results in broad neurological symptoms and an increased
risk of being diagnosed with a neurodegenerative disease later in life. While the immediate …

Repetitive mild traumatic brain injury affects inflammation and excitotoxic mRNA expression at acute and chronic time-points

MI Hiskens, AG Schneiders, RK Vella, AS Fenning - PloS one, 2021 - journals.plos.org
The cumulative effect of mild traumatic brain injuries (mTBI) can result in chronic
neurological damage, however the molecular mechanisms underpinning this detriment …