Hoxb-5 is one of the few homeobox genes strongly expressed in the developing mouse
lung. To explore the hypothesis that Hoxb-5 acts to regulate epithelial cell fate and …

BACKGROUND: We have previously shown that the Hox gene Hoxb‐5 is necessary for
normal mouse lung branching morphogenesis. Abnormal Hoxb‐5 regulation causes specific …

Hox proteins control structural morphogenesis, pattern formation and cell fate in the
developing embryo. To determine if Hoxb-5 participates in patterning of early airway …

Lung development in the mouse begins at embryonic day 9.5 (E9. 5) when lung buds form in
the foregut. Subsequently, there is extensive branching and cellular differentiation that …

BACKGROUND: Hox transcription factors modulate signaling pathways controlling organ
morphogenesis and maintain cell fate and differentiation in adults. Retinoid signaling, key in …

Lung branching morphogenesis is accomplished by reciprocal morphogenetic interactions
between the epithelium and its mesenchyme. In order to better understand the molecular …

Hox genes encode transcription factors governing complex developmental processes in
several organs. A subset of Hox genes are expressed in the developing lung. Except for …

Studies on lung morphogenesis have indicated a role of homeobox (Hox) genes in the
regulation of lung development. In the present study, we attempted to modulate the …

HOX genes belong to the large family of homeodomain genes that function as transcription
factors. Animal studies indicate that they play an essential role in lung development. We …

Hoxa5 is essential for development of several organs and tissues. In the respiratory system,
loss of Hoxa5 function causes neonatal death due to respiratory distress. Expression of …