Paclitaxel production using co-culture of Taxus suspension cells and paclitaxel-producing endophytic fungi in a co-bioreactor

YC Li, WY Tao, L Cheng - Applied microbiology and biotechnology, 2009 - Springer
The co-culture of the suspension cells of Taxus chinensis var. mairei and its endophytic
fungi, Fusarium mairei, in a 20-L co-bioreactor was successfully established for paclitaxel …

Improved paclitaxel production by in situ extraction and elicitation in cell suspension cultures of Taxus chinensis

CH Zhang, HB Xu - Biotechnology letters, 2001 - Springer
Dibutyl phthalate, oleic acid and terpineol were used to extract paclitaxel in situ from Taxus
chinensis suspension cultures. Oleic acid/terpineol (1: 1, v/v) added to the cultures gave a …

New synergistic co-culture of Corylus avellana cells and Epicoccum nigrum for paclitaxel production

M Salehi, A Moieni, N Safaie… - Journal of Industrial …, 2019 - academic.oup.com
Paclitaxel is a main impressive chemotherapeutic agent with unique mode of action and
broad-spectrum activity against cancers. Hazel (Corylus avellana) is a paclitaxel-producing …

Interactions of taxol-producing endophytic fungus with its host (Taxus spp.) during taxol accumulation

YC Li, WY Tao - Cell biology international, 2009 - Elsevier
Endophytic fungi (Fusarium mairei) culture broth (EFCB) was added to cell suspension
cultures of Taxus cuspidata. After 5days, cultures of T. cuspidata given 4ml of EFCB …

Enhancement of paclitaxel production by abscisic acid in cell suspension cultures of Taxus chinensis

J Luo, L Liu, CD Wu - Biotechnology Letters, 2001 - Springer
Addition of 5 mg abscisic acid l− 1 after 12 days' growth of Taxus chinensis suspension
culture gave the greatest paclitaxel accumulation at 11 mg l− 1, which was almost 5 times …

Effects of inoculum size and age on biomass growth and paclitaxel production of elicitor-treated Taxus yunnanensis cell cultures

CH Zhang, JY Wu, GY He - Applied microbiology and biotechnology, 2002 - Springer
Suspension cultures of Taxus yunnanensis cells were inoculated with cells of different
culture ages (12–24 days) at various densities [50–250 g fresh weight (fw)/l], and treated (on …

Enhanced paclitaxel production induced by the combination of elicitors in cell suspension cultures of Taxus chinensis

CH Zhang, XG Mei, L Liu, LJ Yu - Biotechnology Letters, 2000 - Springer
Taxus chinensis suspension cells were cultured in the modified Gamborg's B5 medium.
Addition of 50 mg chitosan l− 1, 60 μM methyl jasmonate and 30 μM Ag+ resulted in the …

Enhancement of Taxol production and excretion in Taxus chinensis cell culture by fungal elicitation and medium renewal

C Wang, J Wu, X Mei - Applied microbiology and biotechnology, 2001 - Springer
An endophytic fungus, Aspergillus niger, isolated from the inner bark of a Taxus chinensis
tree, was used as an elicitor to stimulate the Taxol (paclitaxel) production in a Taxus …

Improved Paclitaxel and Baccatin III Production in Suspension Cultures of Taxusmedia

R M. Cusidó, J Palazón, M Bonfill… - Biotechnology …, 2002 - Wiley Online Library
A cell suspension culture of Taxus media was established from a stable callus line of this
species. The growth rate and production of paclitaxel and baccatin III of this cell suspension …

Taxol-producing fungi: a new approach to industrial production of taxol

JI Yuan, BI Jian-Nan, YAN Bing, Z Xu-Dong - Chinese journal of …, 2006 - Elsevier
Produced by and purified from the Pacific yew Taxus brevifolia, taxol (Paclitaxel) has
become a widely used cancer drug in clinics. Due to the rapid growing market, current …