Cryptococcus neoformans

FL Mayer, JW Kronstad - Trends in microbiology, 2020 - cell.com
The production of a polysaccharide capsule is a critical virulence factor for the AIDS-
associated fungal pathogen Cryptococcus neoformans. Capsule formation is responsive to a …

The Cryptococcus neoformans capsule: a sword and a shield

TR O'Meara, JA Alspaugh - Clinical microbiology reviews, 2012 - Am Soc Microbiol
The human fungal pathogen Cryptococcus neoformans is characterized by its ability to
induce a distinct polysaccharide capsule in response to a number of host-specific …

How Sweet it is! Cell Wall Biogenesis and Polysaccharide Capsule Formation in Cryptococcus neoformans

TL Doering - Annual review of microbiology, 2009 - annualreviews.org
Cryptococcus neoformans is a pathogenic fungus responsible for severe opportunistic
infections. The most prominent feature of this yeast is its elaborate polysaccharide capsule …

[PDF][PDF] Dismantling the Cryptococcus coat

CA D'Souza, J Heitman - Trends in microbiology, 2001 - Citeseer
Cryptococcus neoformans is an encapsulated yeast and an opportunistic fungal pathogen
responsible for lifethreatening infections of the central nervous system (CNS) in HIV-1 …

Unraveling capsule biosynthesis and signaling networks in Cryptococcus neoformans

EH Jang, JS Kim, SR Yu, YS Bahn - Microbiology spectrum, 2022 - Am Soc Microbiol
The polysaccharide capsule of Cryptococcus neoformans—an opportunistic basidiomycete
pathogen and the major etiological agent of fungal meningoencephalitis—is a key virulence …

What makes Cryptococcus neoformans a pathogen?

KL Buchanan, JW Murphy - Emerging infectious diseases, 1998 - ncbi.nlm.nih.gov
Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus
neoformans have been increasing steadily over the past 10 years because of the onset of …

Systematic capsule gene disruption reveals the central role of galactose metabolism on Cryptococcus neoformans virulence

F Moyrand, T Fontaine, G Janbon - Molecular microbiology, 2007 - Wiley Online Library
The polysaccharidic capsule is the main virulence factor of Cryptococcus neoformans. It
primarily comprised of two polysaccharides: glucuronoxylomannan (GXM, 88% of the …

A Quick reCAP: Discovering Cryptococcus neoformans Capsule Mutants

D Boodwa-Ko, TL Doering - Journal of Fungi, 2024 - mdpi.com
Cryptococcus neoformans is an opportunistic fungal pathogen that can cause severe
meningoencephalitis in immunocompromised hosts and is a leading cause of death in …

Elucidating the Immunological Function of the Cryptococcus Neoformans Capsule

A Vecchiarelli, E Pericolini, E Gabrielli… - Future …, 2013 - Taylor & Francis
The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent
of life-threatening infections in immunocompromised subjects. A unique characteristic of …

Analysis of the protein kinase A-regulated proteome of Cryptococcus neoformans identifies a role for the ubiquitin-proteasome pathway in capsule formation

JMH Geddes, M Caza, D Croll, N Stoynov, LJ Foster… - MBio, 2016 - Am Soc Microbiol
The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening
meningitis in immunocompromised individuals. The expression of virulence factors …