Cellular senescence: a link between cancer and age-related degenerative disease?
Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …
The senescence-associated secretory phenotype: the dark side of tumor suppression
JP Coppé, PY Desprez, A Krtolica… - Annual review of …, 2010 - annualreviews.org
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …
risk for malignant transformation. However, accumulating evidence shows that senescent …
[HTML][HTML] The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?
N Ohtani - Inflammation and regeneration, 2022 - Springer
Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has …
variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has …
[HTML][HTML] Senescent cells as a source of inflammatory factors for tumor progression
AR Davalos, JP Coppe, J Campisi… - Cancer and Metastasis …, 2010 - Springer
Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …
Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
N Ohtani, E Hara - Cancer science, 2013 - Wiley Online Library
Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …
[HTML][HTML] Senescence and tumor suppression
P Hinds, J Pietruska - F1000Research, 2017 - ncbi.nlm.nih.gov
Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …
proliferation of cells at risk for malignant transformation. Although senescent cells have …
Cellular senescence and the tumour microenvironment
M Takasugi, Y Yoshida, N Ohtani - Molecular oncology, 2022 - Wiley Online Library
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …
Cellular senescence and tumor promotion: Is aging the key?
N Loaiza, M Demaria - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2016 - Elsevier
The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …
irreversible growth arrest in response to potentially oncogenic signals to prevent the …
Senescent cells and their secretory phenotype as targets for cancer therapy
MC Velarde, M Demaria, J Campisi - Cancer and Aging, 2013 - karger.com
Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …
[HTML][HTML] Context-dependent effects of cellular senescence in cancer development
P Lecot, F Alimirah, PY Desprez, J Campisi… - British journal of …, 2016 - nature.com
Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …
proliferation of premalignant cells. However, several lines of evidence show that senescent …
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