Highlights•MHC-I molecules exhibit allotype-dependent conformational flexibility, which is
critical for their function.•Peptide-deficient MHC-I adopt distinct groove conformations …

CD8+ T cell immunosurveillance is based on recognizing oligopeptides presented by MHC
class I molecules. Despite decades of study, the importance of protein ubiquitylation to …

Presentation of antigenic peptides on MHC-II molecules is essential for tolerance to self and
for initiation of immune responses against foreign antigens. DO (HLA-DO in humans, H2-O …

Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …

Over the past year, several important advances have been made in understanding the
mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside …

The ectodomains of interacting membrane-bound proteins, when expressed as recombinant
soluble molecules, often have low affinities for each other, hampering studies of their …

Abstract HLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound
peptides in endocytic compartments and stabilizes empty MHCII molecules. Crystal …

During the assembly of MHC class I molecules with peptide, a series of transient interactions
are made with endoplasmic reticulum-resident chaperones and MHC class I-specific …

Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …