Normal immune surveillance depends on the ability of MHC class II molecules to bind
peptide antigens and carry them to the cell surface for display to T cells. To do this efficiently …

The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major
histocompatibility (MHC) class II molecules during antigen processing; however, the …

Major histocompatibihty complex (MHC)‐encoded glycoproteins bind peptide antigens
through non‐covalent interactions to generate complexes that are displayed on tbe surface …

Major histocompatibility complex class I molecules (MHC I) help protect jawed vertebrates
by binding and presenting immunogenic peptides to cytotoxic T lymphocytes. Peptides are …

Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …

MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these
molecules function by binding antigenic peptides and presenting these peptides to antigen …

Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

Summary Major Histocompatibility Complex (MHC) class II molecules, including Human
Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the …

Class II MHC molecules display peptides on the cell surface for the surveillance by CD4+ T
cells. To ensure that these ligands accurately reflect the content of the intracellular MHC …

The tremendous explosion in the field of MHC research in the last 5 years has significantly
advanced our understanding of antigen processing pathways, particularly with regard to …