White adipose tissue: getting nervous

E Fliers, F Kreier, PJ Voshol… - Journal of …, 2003 - Wiley Online Library
Neuroendocrine research has altered the traditional perspective of white adipose tissue
(WAT) as a passive store of triglycerides. In addition to fatty acids, WAT produces many …

White adipose tissue sensory nerve denervation mimics lipectomy-induced compensatory increases in adiposity

H Shi, TJ Bartness - American Journal of Physiology …, 2005 - journals.physiology.org
The sensory innervation of white adipose tissue (WAT) is indicated by the labeling of
sensory bipolar neurons in the dorsal root ganglion after retrograde dye placement into …

[HTML][HTML] Leptin and insulin act on POMC neurons to promote the browning of white fat

GT Dodd, S Decherf, K Loh, SE Simonds, F Wiede… - Cell, 2015 - cell.com
The primary task of white adipose tissue (WAT) is the storage of lipids. However," beige"
adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate the energy as heat …

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

AW Fischer, C Schlein, B Cannon… - American Journal …, 2019 - journals.physiology.org
The possibility that recruitment and activation of brown adipose tissue (BAT) thermogenesis
could be beneficial for curtailing obesity development in humans prompts a need for a better …

Central pathways controlling brown adipose tissue thermogenesis

SF Morrison - Physiology, 2004 - journals.physiology.org
Heat production in brown adipose tissue contributes to cold defense, to stress-induced
increases in body temperature, and to energy balance. Elucidating the functional …

Adipose tissue in communication: within and without

YH Tseng - Nature Reviews Endocrinology, 2023 - nature.com
Adipose tissue is highly versatile, dynamic and essential for metabolic health. In 2022,
several exciting discoveries provided a high-resolution view of cellular composition and cell …

Leptin and brain–adipose crosstalks

A Caron, S Lee, JK Elmquist, L Gautron - Nature Reviews …, 2018 - nature.com
Interactions between the brain and distinct adipose depots have a key role in maintaining
energy balance, thereby promoting survival in response to metabolic challenges such as …

Translational pharmacology and physiology of brown adipose tissue in human disease and treatment

CJ Larson - Brown Adipose Tissue, 2019 - Springer
Human brown adipose tissue (BAT) is experimentally modeled to better understand the
biology of this important metabolic tissue, and also to enable the potential discovery and …

Regulation of lipid metabolism by energy availability: a role for the central nervous system

R Nogueiras, M Lopez, C Dieguez - Obesity Reviews, 2010 - Wiley Online Library
The central nervous system (CNS) is crucial in the regulation of energy homeostasis. Many
neuroanatomical studies have shown that the white adipose tissue (WAT) is innervated by …

The brown adipocyte: update on its metabolic role

H Sell, Y Deshaies, D Richard - The international journal of biochemistry & …, 2004 - Elsevier
Brown adipocytes are multilocular lipid storage cells that play a crucial role in non-shivering
thermogenesis. These cells are located in brown adipose tissue (BAT) depots which are …