Importance Dietary modification remains key to successful weight loss. Yet, no one dietary
strategy is consistently superior to others for the general population. Previous research …

Weight loss (WL) differences between isocaloric high-carbohydrate and high-fat diets are
generally small; however, individual WL varies within diet groups. Genotype patterns may …

ContextThe results of clinical trials involving diet in the treatment of obesity have been
inconsistent, possibly due to inherent physiological differences among study participants …

Low‐carbohydrate diets have been associated with significant reductions in weight and
HbA1c in obese, diabetic participants who received high‐intensity lifestyle modification for 6 …

Background Trials comparing the effectiveness and safety of weight-loss diets are frequently
limited by short follow-up times and high dropout rates. Methods In this 2-year trial, we …

Dietary modification is central to obesity treatment. Weight loss diets are available that
include various permutations of energy restriction, macronutrients, foods, and dietary intake …

Background: Clinical trials of low-fat diets characteristically produce small mean long-term
weight loss but a large interindividual variation in response. This variation has been …

Background The effectiveness of low-fat diets for long-term weight loss has been debated for
decades, with many randomised controlled trials (RCTs) and recent reviews giving mixed …

Background The existence of metabolic adaptation, at the level of resting metabolic rate
(RMR), remains highly controversial, likely due to lack of standardization of participants' …

Obesity is an established risk factor for numerous chronic diseases, and successful
treatment will have an important impact on medical resources utilization, health care costs …