Can acute overdose of metformin lead to lactic acidosis?

BK Wills, SM Bryant, P Buckley, B Seo - The American journal of emergency …, 2010 - Elsevier
INTRODUCTION: Metformin-associated lactic acidosis (MALA) is well described in patients
taking therapeutic metformin who develop renal failure or other serious comorbid conditions …

Hyperlactataemia and clinical severity of acute metformin overdose

K McNamara, GK Isbister - Internal medicine journal, 2015 - Wiley Online Library
Background Although metformin‐associated lactic acidosis is well described, there is less
information on metformin overdose and whether it is of similar severity. Aims This study aims …

Metformin overdose with a resultant serum pH of 6.59: survival without sequalae

DM Dell'Aglio, LJ Perino, JD Todino, DA Algren… - The Journal of …, 2010 - Elsevier
Metformin, widely used in the treatment of diabetes mellitus, is known to cause lactic
acidosis in both therapeutic use and after an overdose. We report the case of a 40-year-old …

Occult metformin toxicity in three patients with profound lactic acidosis

J Perrone, C Phillips, D Gaieski - The Journal of emergency medicine, 2011 - Elsevier
There are 20.8 million Americans with diabetes, and metformin is the most commonly
prescribed oral diabetes agent. A review of our metformin experience highlights common …

Time to development of metformin-associated lactic acidosis

J Theobald, J Schneider, N Cheema… - Clinical …, 2020 - Taylor & Francis
Objective: Metformin-associated lactic acidosis (MALA) is a complication of metformin
overdose. Recommendations for observation time after an acute ingestion to monitor for …

Metformin-induced lactic acidosis (MILA): review of current diagnostic paradigm

L Krowl, H Al-Khalisy, P Kaul - The American journal of emergency …, 2018 - Elsevier
A new diagnostic paradigm has been proposed to better categorize causes of Metformin-
Associated Lactic Acidosis (MALA). The diagnostic criteria defines a link between Metformin …

Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature

DM Dell'Aglio, LJ Perino, Z Kazzi, J Abramson… - Annals of emergency …, 2009 - Elsevier
STUDY OBJECTIVE: Metformin is known to cause potentially fatal metabolic acidosis with
an increased lactate level in both overdose and therapeutic use. No association between …

Lactic acidosis secondary to metformin overdose: a case report

S Timbrell, G Wilbourn, J Harper, A Liddle - Journal of Medical Case …, 2012 - Springer
Introduction Metformin is a commonly used treatment modality in type 2 diabetes mellitus,
with a well documented side effect of lactic acidosis. In the intensive care setting lactate and …

The MALAdy of metformin poisoning: is CVVH the cure?

AM Arroyo, TA Walroth, JB Mowry… - American journal of …, 2010 - journals.lww.com
Inadvertent or intentional metformin overdose can result in death from refractory lactic
acidosis. We report a death from metformin-induced refractory lactic acidosis despite …

Metformin-associated lactic acidosis presenting as acute ST-elevation myocardial infarction

S White, BE Driver, JB Cole - The Journal of emergency medicine, 2016 - Elsevier
Background Metformin-associated lactic acidosis (MALA) is a rare but life-threatening
adverse drug reaction of metformin, the most frequently prescribed medication for patients …