Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …

The underlying principles of sepsis therapy have remained unchanged for decades. These
include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source …

Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …

Sepsis, which refers to a systemic inflammatory response syndrome resulting from a
microbial infection, represents the leading cause of death in intensive care units. The …

Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Severe sepsis leading to shock is the principal cause of death in non-cardiac intensive care
units. This condition develops because of a dysregulation in host responses, such that the …

Sepsis is among the leading causes of death worldwide and its incidence is increasing.
Defined as the host response to infection, sepsis is a clinical syndrome considered to be the …

Sepsis and septic shock lead to considerable morbidity and mortality in developed and
developing countries. Despite advances in understanding the innate immune events that …

The pathogenesis of sepsis involves not only microbial toxins but also activated host
inflammatory mediators. Therefore, besides conventional antibiotic or surgical treatment of …

Sepsis is a syndrome related to severe infections. It is defined as the systemic host response
to microorganisms in previously sterile tissues and is characterized by end-organ …