Future perspectives on regulating pro-and anti-inflammatory responses in sepsis
D Delsesto, SM Opal - Sepsis-Pro-Inflammatory and Anti-Inflammatory …, 2011 - karger.com
Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …
treatments to regulate the disordered inflammatory response in sepsis are needed if …
Experimental and emerging therapies for sepsis and septic shock
RL Añel, A Kumar - Expert opinion on investigational drugs, 2001 - Taylor & Francis
The underlying principles of sepsis therapy have remained unchanged for decades. These
include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source …
include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source …
Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses
Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …
[HTML][HTML] An ongoing search for potential targets and therapies for lethal sepsis
Sepsis, which refers to a systemic inflammatory response syndrome resulting from a
microbial infection, represents the leading cause of death in intensive care units. The …
microbial infection, represents the leading cause of death in intensive care units. The …
Current trends in inflammatory and immunomodulatory mediators in sepsis
Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …
Therapeutic approaches to innate immunity: severe sepsis and septic shock
Severe sepsis leading to shock is the principal cause of death in non-cardiac intensive care
units. This condition develops because of a dysregulation in host responses, such that the …
units. This condition develops because of a dysregulation in host responses, such that the …
Host innate immune responses to microbial pathogens
J Delaloye, T Calandra - Current vascular pharmacology, 2013 - ingentaconnect.com
Sepsis is among the leading causes of death worldwide and its incidence is increasing.
Defined as the host response to infection, sepsis is a clinical syndrome considered to be the …
Defined as the host response to infection, sepsis is a clinical syndrome considered to be the …
Inflection points in sepsis biology: from local defense to systemic organ injury
EJ Seeley, MA Matthay… - American Journal of …, 2012 - journals.physiology.org
Sepsis and septic shock lead to considerable morbidity and mortality in developed and
developing countries. Despite advances in understanding the innate immune events that …
developing countries. Despite advances in understanding the innate immune events that …
Immune modulation and sepsis
W Karzai, K Reinhart - International journal of clinical practice, 1997 - Wiley Online Library
The pathogenesis of sepsis involves not only microbial toxins but also activated host
inflammatory mediators. Therefore, besides conventional antibiotic or surgical treatment of …
inflammatory mediators. Therefore, besides conventional antibiotic or surgical treatment of …
[HTML][HTML] Sepsis: from bench to bedside
E Silva, RDH Passos, MB Ferri, LFP de Figueiredo - Clinics, 2008 - Elsevier
Sepsis is a syndrome related to severe infections. It is defined as the systemic host response
to microorganisms in previously sterile tissues and is characterized by end-organ …
to microorganisms in previously sterile tissues and is characterized by end-organ …