Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in
patients with aneurysmal subarachnoid hemorrhage (aSAH), defining an unmet need for …

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating form of stroke frequently
affecting young to middle-aged adults, with an unmet need to improve outcome. This special …

After subarachnoid haemorrhage, prolonged exposure to toxic extracellular haemoglobin
occurs in the brain. Here, we investigate the role of haemoglobin neurotoxicity in vivo and its …

Haemoglobin is released into the CNS during the breakdown of red blood cells after
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …

Abstract Haptoglobin (Hp) binds hemoglobin (Hb) with high affinity and provides the primary
defense against its toxicity after intravascular hemolysis. Neurons are exposed to …

Delayed cerebral ischemia (DCI) continues to be a sequela of aneurysmal subarachnoid
hemorrhage (aSAH) that carries significant morbidity and mortality. Aside from nimodipine …

Background Aneurysmal subarachnoid hemorrhage (aSAH) is often complicated by the
occurrence of delayed ischemic neurologic deficits (DIND), which impairs the clinical …

Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) contributes to
poor outcomes in patients after rupture of an intracranial aneurysm. The lack of diagnostic …

After intracerebral hemorrhage (ICH), the brain parenchyma is exposed to blood containing
red blood cells (RBCs) and consequently to its lysis products. Iron-rich hemoglobin (Hb) is …

Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological
deficits. Much of this is related to the effects of blood in the subarachnoid space which …