Enrichment of disease-associated genes in cortical areas defined by transcriptome-based parcellation

G Gryglewski, M Murgaš, M Klöbl, MB Reed… - Biological Psychiatry …, 2022 - Elsevier
Background Parcellation of the cerebral cortex serves the investigation of the emergence of
uniquely human brain functions and disorders. Transcriptome data enable the …

Integration of tissue-specific multi-omics data implicates brain targets for complex neuropsychiatric traits

S Cong, Z Sang, L Cao, J Yuan, Y Li, H Liang, X Yao - medRxiv, 2023 - medrxiv.org
Genome-wide association studies (GWAS) have uncovered genetic variants susceptible to
brain disorders. However, due to the complex pathogenesis of these diseases and …

[引用][C] Navigating a complex landscape: using transcriptomics to parcellate the human cortex

JM Shine, A Arnatkeviciute… - Biological …, 2022 - biologicalpsychiatrycnni.org
Gryglewski et al.(1) provide a pertinent example of this approach that aims to delineate the
spatial organization of molecular diversity in the brain by developing a transcriptomebased …

Global gene expression profiling of healthy human brain and its application in studying neurological disorders

SK Negi, C Guda - Scientific reports, 2017 - nature.com
Brain function is governed by precise regulation of gene expression across its anatomically
distinct structures; however, the expression patterns of genes across hundreds of brain …

Transcriptional cartography integrates multiscale biology of the human cortex

K Wagstyl, S Adler, J Seidlitz, S Vandekar, TT Mallard… - Elife, 2024 - elifesciences.org
The cerebral cortex underlies many of our unique strengths and vulnerabilities, but efforts to
understand human cortical organization are challenged by reliance on incompatible …

A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases

Y Zeighami, TE Bakken, T Nickl-Jockschat… - PLoS …, 2023 - journals.plos.org
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …

DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles

SJ Evans, PV Choudary, MP Vawter, J Li… - Neurobiology of …, 2003 - Elsevier
Transcriptional profiles within discrete human brain regions are likely to reflect structural and
functional specialization. Using DNA microarray technology, this study investigates …

The architecture of brain co-expression reveals the brain-wide basis of disease susceptibility

CL Hartl, G Ramaswami, WG Pembroke, S Muller… - Biorxiv, 2020 - biorxiv.org
Gene networks have proven their utility for elucidating transcriptome structure in the brain,
yielding numerous biological insights. Most analyses have focused on expression …

Transcriptional signatures of connectomic subregions of the human striatum

L Parkes, BD Fulcher, M Yücel… - Genes, Brain and …, 2017 - Wiley Online Library
Functionally distinct regions of the brain are thought to possess a characteristic connectional
fingerprint–a profile of incoming and outgoing connections that defines the function of that …

Structural and cellular transcriptome foundations of human brain disease

Y Zeighami, TE Bakken, T Nickl-Jockschat, Z Peterson… - bioRxiv, 2021 - biorxiv.org
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …