Enrichment of disease-associated genes in cortical areas defined by transcriptome-based parcellation
G Gryglewski, M Murgaš, M Klöbl, MB Reed… - Biological Psychiatry …, 2022 - Elsevier
Background Parcellation of the cerebral cortex serves the investigation of the emergence of
uniquely human brain functions and disorders. Transcriptome data enable the …
uniquely human brain functions and disorders. Transcriptome data enable the …
Integration of tissue-specific multi-omics data implicates brain targets for complex neuropsychiatric traits
Genome-wide association studies (GWAS) have uncovered genetic variants susceptible to
brain disorders. However, due to the complex pathogenesis of these diseases and …
brain disorders. However, due to the complex pathogenesis of these diseases and …
[引用][C] Navigating a complex landscape: using transcriptomics to parcellate the human cortex
JM Shine, A Arnatkeviciute… - Biological …, 2022 - biologicalpsychiatrycnni.org
Gryglewski et al.(1) provide a pertinent example of this approach that aims to delineate the
spatial organization of molecular diversity in the brain by developing a transcriptomebased …
spatial organization of molecular diversity in the brain by developing a transcriptomebased …
Global gene expression profiling of healthy human brain and its application in studying neurological disorders
Brain function is governed by precise regulation of gene expression across its anatomically
distinct structures; however, the expression patterns of genes across hundreds of brain …
distinct structures; however, the expression patterns of genes across hundreds of brain …
Transcriptional cartography integrates multiscale biology of the human cortex
The cerebral cortex underlies many of our unique strengths and vulnerabilities, but efforts to
understand human cortical organization are challenged by reliance on incompatible …
understand human cortical organization are challenged by reliance on incompatible …
A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …
DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles
Transcriptional profiles within discrete human brain regions are likely to reflect structural and
functional specialization. Using DNA microarray technology, this study investigates …
functional specialization. Using DNA microarray technology, this study investigates …
The architecture of brain co-expression reveals the brain-wide basis of disease susceptibility
Gene networks have proven their utility for elucidating transcriptome structure in the brain,
yielding numerous biological insights. Most analyses have focused on expression …
yielding numerous biological insights. Most analyses have focused on expression …
Transcriptional signatures of connectomic subregions of the human striatum
Functionally distinct regions of the brain are thought to possess a characteristic connectional
fingerprint–a profile of incoming and outgoing connections that defines the function of that …
fingerprint–a profile of incoming and outgoing connections that defines the function of that …
Structural and cellular transcriptome foundations of human brain disease
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …